ABNORMAL RETINAL POTENTIALS IN GLAUCOMA AND OCULAR HYPER

模式反转视网膜电位（PRRP）是生物电信号， 在近端视网膜层内产生，这可以从 当观察相位交替刺激时人眼的角膜。 我们 以前的研究表明，PRRP振幅显著 与原发性开角型青光眼（POAG）患者相比， 年龄匹配的视觉正常值（AMVN）。 此外，我们的研究结果表明， 这种PRRP幅度降低的幅度在视觉上是最大的， 刺激以高时间速率相位交替（即， 第二）。 这表明POAG的发展产生了高的 人的时间调谐特性中的频率衰减 PRRP。 此外，我们注意到高眼压患者 (OHT)老年视觉正常者（70-79岁）可能表现出PRRP 高时间频率刺激的幅度减小。 这些 观察提出了以下三个假设，将在 建议的研究：1）PRRP幅度的降低提供了 可靠的预后指标，其中眼高血压将发展 POAG（纵向研究），2）PRRP振幅显著降低， 低眼压性青光眼患者（横断面研究）和3）正常 生理老化产生PRRP振幅的进行性降低（a 横截面研究）。

Pattern-reversal retinal potentials (PRRPs) are bioelectrical signals, generated within the proximal retinal layers, which can be recorded from the cornea of the human eye when phase-alternating stimuli are viewed. Our previous investigations have revealed that PRRP amplitude is significantly reduced in patients with primary open-angle glaucoma (POAG) relative to age-matched visual normals (AMVNs). Furthermore, our results indicate that the magnitude of this PRRP amplitude reduction is greatest when the visual stimuli are phase-alternated at a high temporal rate (i.e. 16 reversals per second). This suggests that the development of POAG produces a high frequency attenuation in the temporal tuning characteristic of the human PRRP. Additionally, we have noted that patients with ocular hypertension (OHT) and elderly visual normals (70-79 years of age) may exhibit PRRP amplitude reductions for high temporal frequency stimuli. These observations suggest the following three hypotheses which will be tested in the proposed investigation: 1) Reductions in PRRP amplitude provide reliable prognostic indications of which ocular hypertensives will develop POAG (a longitudinal study), 2) PRRP amplitude is significantly reduced in patients with low tension glaucoma (a cross-sectional study) and 3) normal physiological aging produces progressive reductions in PRRP amplitude (a cross-sectional study).