ABNORMAL RETINAL POTENTIALS IN GLAUCOMA AND OCULAR HYPER

青光眼和远视眼的视网膜电位异常

基本信息

  • 批准号:
    3261987
  • 负责人:
  • 金额:
    $ 12.37万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1985
  • 资助国家:
    美国
  • 起止时间:
    1985-01-01 至 1991-03-31
  • 项目状态:
    已结题

项目摘要

Pattern-reversal retinal potentials (PRRPs) are bioelectrical signals, generated within the proximal retinal layers, which can be recorded from the cornea of the human eye when phase-alternating stimuli are viewed. Our previous investigations have revealed that PRRP amplitude is significantly reduced in patients with primary open-angle glaucoma (POAG) relative to age-matched visual normals (AMVNs). Furthermore, our results indicate that the magnitude of this PRRP amplitude reduction is greatest when the visual stimuli are phase-alternated at a high temporal rate (i.e. 16 reversals per second). This suggests that the development of POAG produces a high frequency attenuation in the temporal tuning characteristic of the human PRRP. Additionally, we have noted that patients with ocular hypertension (OHT) and elderly visual normals (70-79 years of age) may exhibit PRRP amplitude reductions for high temporal frequency stimuli. These observations suggest the following three hypotheses which will be tested in the proposed investigation: 1) Reductions in PRRP amplitude provide reliable prognostic indications of which ocular hypertensives will develop POAG (a longitudinal study), 2) PRRP amplitude is significantly reduced in patients with low tension glaucoma (a cross-sectional study) and 3) normal physiological aging produces progressive reductions in PRRP amplitude (a cross-sectional study).
模式反转视网膜电位(prrp)是一种生物电信号,

项目成果

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GARY L TRICK其他文献

GARY L TRICK的其他文献

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{{ truncateString('GARY L TRICK', 18)}}的其他基金

fMRI Studies of Retinal Oxygenation in Diabetic Patients
糖尿病患者视网膜氧合的功能磁共振成像研究
  • 批准号:
    6561268
  • 财政年份:
    2003
  • 资助金额:
    $ 12.37万
  • 项目类别:
fMRI Studies of Retinal Oxygenation in Diabetic Patients
糖尿病患者视网膜氧合的功能磁共振成像研究
  • 批准号:
    6756416
  • 财政年份:
    2003
  • 资助金额:
    $ 12.37万
  • 项目类别:
ABNORMAL RETINAL POTENTIALS IN GLAUCOMA AND OCULAR HYPER
青光眼和远视眼的视网膜电位异常
  • 批准号:
    3261985
  • 财政年份:
    1985
  • 资助金额:
    $ 12.37万
  • 项目类别:
ABNORMAL RETINAL POTENTIALS IN GLAUCOMA AND OCULAR HYPER
青光眼和远视眼的视网膜电位异常
  • 批准号:
    3261988
  • 财政年份:
    1985
  • 资助金额:
    $ 12.37万
  • 项目类别:
ABNORMAL RETINAL POTENTIAL--GLAUCOMA OCULAR HYPERTENSION
视网膜电位异常--青光眼眼高压
  • 批准号:
    3261990
  • 财政年份:
    1985
  • 资助金额:
    $ 12.37万
  • 项目类别:
ABNORMAL RETINAL POTENTIAL--GLAUCOMA OCULAR HYPERTENSION
视网膜电位异常--青光眼眼高压
  • 批准号:
    3261989
  • 财政年份:
    1985
  • 资助金额:
    $ 12.37万
  • 项目类别:

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