OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM

视觉系统中的振荡电位

基本信息

  • 批准号:
    3257788
  • 负责人:
  • 金额:
    $ 5.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1980
  • 资助国家:
    美国
  • 起止时间:
    1980-07-01 至 1988-09-29
  • 项目状态:
    已结题

项目摘要

In the previously funded period, I have succeeded in achieving stimulation and recording conditions which allow for the repeated and reliable recording of light evoked high frequency wavelets ("oscillatory potentials"), which are obtained from the occipital scalp in man. The specific aims of this project are directed toward further understanding of the characteristics and origins of light evoked electrophysiological activity of the human visual system, and toward the application of these measures to the diagnosis of visual system anomalies and disease. The following plan is proposed to achieve these aims: Phase I: Investigation of the development of VEP wavelets in newborns and infants. Included in Phase I will be a comparison of the developmental sequence of occipital VEP wavelets and slow waves; an analysis of the functions of wavelet and slow wave amplitude and implicit time as related to stimulus flash intensity; and an analysis in terms of the possible progression from subcortical to cortical visual mechanisms in the developing infant. Phase II: Investigation of specific properties and relationships of wavelets recorded at the eye (ERG) and at the scalp (VEP). Included in Phase II will be the determination of specific relationships between the various VEP wavelets and the temporally preceding electroretinogram (ERG) wavelets; investigation of the effects of different electrical reference sites upon the scalp distribution of VEP wavelets; investigation of the differences in spatial frequency tuning as reflected in the amplitude of wavelets and slow waves. Phase III: Investigation of the use of VEP wavelets for the diagnosis of visual system anomalies and disease. Included in Phase III will be inter-ocular comparisons of VEP wavelets in normal subjects; the determination of the changes in VEP wavelets in afferent optic nerve transmission deficits; and the determination of the changes in VEP wavelets in diabetic retinopathy. ERG and VEP signals will be recorded and computer analyzed, using newly-developed digital filtering techniques. Light stimuli will be carefully calibrated and controlled. The recording of high frequency VEP wavelets appears to represent significant advantages over the traditional recording of slower (lower frequency) waves from occipital scalp, chief among which is the relatively greater precision of measurement of peak latencies.
在之前的资助期内,我已经成功地实现了刺激

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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JOHN B SIEGFRIED其他文献

JOHN B SIEGFRIED的其他文献

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{{ truncateString('JOHN B SIEGFRIED', 18)}}的其他基金

VISUAL DEFICITS IN ALZHEIMER'S DISEASE
阿尔茨海默病的视力缺陷
  • 批准号:
    2268373
  • 财政年份:
    1991
  • 资助金额:
    $ 5.91万
  • 项目类别:
VISUAL DEFICITS IN ALZHEIMER'S DISEASE
阿尔茨海默病的视力缺陷
  • 批准号:
    3417268
  • 财政年份:
    1991
  • 资助金额:
    $ 5.91万
  • 项目类别:
VISUAL DEFICITS IN ALZHEIMER'S DISEASE
阿尔茨海默病的视力缺陷
  • 批准号:
    3417267
  • 财政年份:
    1991
  • 资助金额:
    $ 5.91万
  • 项目类别:
OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM
视觉系统中的振荡电位
  • 批准号:
    3257789
  • 财政年份:
    1980
  • 资助金额:
    $ 5.91万
  • 项目类别:
OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM
视觉系统中的振荡电位
  • 批准号:
    3257787
  • 财政年份:
    1980
  • 资助金额:
    $ 5.91万
  • 项目类别:
OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM
视觉系统中的振荡电位
  • 批准号:
    3257786
  • 财政年份:
    1980
  • 资助金额:
    $ 5.91万
  • 项目类别:

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