OSCILLATORY POTENTIALS IN THE VISUAL SYSTEM
视觉系统中的振荡电位
基本信息
- 批准号:3257788
- 负责人:
- 金额:$ 5.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1980
- 资助国家:美国
- 起止时间:1980-07-01 至 1988-09-29
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In the previously funded period, I have succeeded in achieving stimulation
and recording conditions which allow for the repeated and reliable
recording of light evoked high frequency wavelets ("oscillatory
potentials"), which are obtained from the occipital scalp in man. The
specific aims of this project are directed toward further understanding of
the characteristics and origins of light evoked electrophysiological
activity of the human visual system, and toward the application of these
measures to the diagnosis of visual system anomalies and disease. The
following plan is proposed to achieve these aims: Phase I: Investigation
of the development of VEP wavelets in newborns and infants. Included in
Phase I will be a comparison of the developmental sequence of occipital VEP
wavelets and slow waves; an analysis of the functions of wavelet and slow
wave amplitude and implicit time as related to stimulus flash intensity;
and an analysis in terms of the possible progression from subcortical to
cortical visual mechanisms in the developing infant. Phase II:
Investigation of specific properties and relationships of wavelets recorded
at the eye (ERG) and at the scalp (VEP). Included in Phase II will be the
determination of specific relationships between the various VEP wavelets
and the temporally preceding electroretinogram (ERG) wavelets;
investigation of the effects of different electrical reference sites upon
the scalp distribution of VEP wavelets; investigation of the differences in
spatial frequency tuning as reflected in the amplitude of wavelets and slow
waves. Phase III: Investigation of the use of VEP wavelets for the
diagnosis of visual system anomalies and disease. Included in Phase III
will be inter-ocular comparisons of VEP wavelets in normal subjects; the
determination of the changes in VEP wavelets in afferent optic nerve
transmission deficits; and the determination of the changes in VEP wavelets
in diabetic retinopathy. ERG and VEP signals will be recorded and computer
analyzed, using newly-developed digital filtering techniques. Light
stimuli will be carefully calibrated and controlled. The recording of high
frequency VEP wavelets appears to represent significant advantages over the
traditional recording of slower (lower frequency) waves from occipital
scalp, chief among which is the relatively greater precision of measurement
of peak latencies.
在之前的资助期内,我已经成功地实现了刺激
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN B SIEGFRIED其他文献
JOHN B SIEGFRIED的其他文献
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{{ truncateString('JOHN B SIEGFRIED', 18)}}的其他基金
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