olecular mechanisms of protein transport through photoreceptor cilia in light/dark adaptation

我们发现脊椎动物纤毛运动蛋白马达之间的功能关系是多样化的，我们的数据表明，在某些纤毛分化过程中，纤毛运动蛋白马达的谱系发生了变化。我们还在Mak缺陷小鼠的视网膜外核层发现了转导蛋白的异位聚集，提示Mak可能参与了转导蛋白通过光感受器外节和内节之间纤毛运输的分子机制。

We found that diversity of functional relationships between vertebrate ciliary kinesin motors, and our data shows that the repertoire of kinesin motors changes in some cilia during their differentiation. We also identified ectopic accumulation of transducin in the retinal outer nuclear layer of Mak deficient mice, suggesting the possibility that involvement of Mak in the molecular mechanism of transducin transport through cilia between the photoreceptor outer segments and inner segments.