The Epigenetics of Sex in the Dragon

龙性别的表观遗传学

• 批准号: DP220101429
• 负责人: Prof Arthur Georges
• 金额: $ 89.21万
• 依托单位: University of Canberra
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101429
• 关键词: Epigenetics; Sex; Dragon

Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.

遗传密码并不直接转化为表型-环境通过表观遗传学改变发育。我们使用先进的分子技术来研究表观遗传学如何对温度做出反应，以逆转我们的新动物模型龙蜥蜴的性别。细胞如何感知温度？一旦外源信号被捕获，它如何影响染色质修饰以释放或抑制性别分化途径中的关键基因？哪些性基因是目标？ 表观遗传酶是非常保守的，提供了令人兴奋的机会，从人类系统中提取解开温度诱导的爬行动物性别转换的新签名。这个项目将促进一般发展规划的知识。