NATURAL PRODUCT SYNTHESIS USING ORGANOIRON REAGENTS

硫霉素及其类似物的合成将是 采用烷基、酰基和烯铁络合物作为合成子 和中间体，促进碳-碳的形成和 碳-氮键。青霉酸6-氨基的全合成 青霉酸及其类似物，包括咪唑， 恶唑、嘧啶、嘌呤和蝶啶融合的β-内酰胺环也将 要承担的责任。阳离子乙烯基醚-铁络合物在有机合成中的应用 将乙烯基α引入到羰基上，并用于 α-亚甲基-伽马-内酯包合物的构建 我们将研究它的功能。在具体的综合目标中 是美罗喹、燕麦内酯、异燕麦内酯、根瘤菌毒素和 马兜铃内酯。

The synthesis of thienomycin and analogs of this substance will be undertaken employing alkyl-, acyl- and olefin-iron complexes as synthons and intermediates to promote the formation of carbon-carbon and carbon-nitrogen bonds. The total synthesis of penicillanic acid, 6-amino penicillanic acid and analogs of the penam nucleus, including imidazole, oxazole, pyrimidine, purine and pteridine fused beta-lactam rings will also be undertaken. The use of cationic vinyl ether-iron complexes for the introduction of vinyl groups Alpha to carbonyl functions and for the construction of substances incorporating the Alpha-methylene Gamma-lactone functionality will be examined. Among the specific synthetic objectives are meroquinene, avenaciolide, isoavenaciolide, rhizobitoxine and aristolactone.