NATURAL PRODUCT SYNTHESIS USING ORGANOIRON REAGENTS

噻吩霉素和该物质类似物的合成将是 采用烷基-、酰基-和烯烃-铁络合物作为配体进行 和中间体以促进碳-碳的形成， 碳氮键 氨基青霉烷酸的全合成 青霉烷酸和青霉烷核的类似物，包括咪唑， 唑、嘧啶、嘌呤和蝶啶稠合的β-内酰胺环也将 进行。 阳离子乙烯基醚-铁络合物用于 将乙烯基α引入羰基官能团， 掺入α-亚甲基γ-内酯的物质的结构 功能将被检查。 在具体的综合目标中 是meroquinene，avenacidine，isoavenacidine，根瘤菌毒素和 马兜铃内酯

The synthesis of thienomycin and analogs of this substance will be undertaken employing alkyl-, acyl- and olefin-iron complexes as synthons and intermediates to promote the formation of carbon-carbon and carbon-nitrogen bonds. The total synthesis of penicillanic acid, 6-amino penicillanic acid and analogs of the penam nucleus, including imidazole, oxazole, pyrimidine, purine and pteridine fused beta-lactam rings will also be undertaken. The use of cationic vinyl ether-iron complexes for the introduction of vinyl groups Alpha to carbonyl functions and for the construction of substances incorporating the Alpha-methylene Gamma-lactone functionality will be examined. Among the specific synthetic objectives are meroquinene, avenaciolide, isoavenaciolide, rhizobitoxine and aristolactone.