NATURAL PRODUCT SYNTHESIS USING ORGANOIRON REAGENTS

使用有机铁试剂合成天然产物

• 批准号: 3268915
• 负责人: MYRON ROSENBLUM
• 金额: $ 11.59万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-09-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3268915
• 关键词: beta lactam antibiotic; drug design /synthesis /production; imidazole; oxazoles; prostaglandins; pteridines; purines; pyrimidines

The synthesis of thienomycin and analogs of this substance will be undertaken employing alkyl-, acyl- and olefin-iron complexes as synthons and intermediates to promote the formation of carbon-carbon and carbon-nitrogen bonds. The total synthesis of penicillanic acid, 6-amino penicillanic acid and analogs of the penam nucleus, including imidazole, oxazole, pyrimidine, purine and pteridine fused beta-lactam rings will also be undertaken. The use of cationic vinyl ether-iron complexes for the introduction of vinyl groups Alpha to carbonyl functions and for the construction of substances incorporating the Alpha-methylene Gamma-lactone functionality will be examined. Among the specific synthetic objectives are meroquinene, avenaciolide, isoavenaciolide, rhizobitoxine and aristolactone.

本文将介绍硫霉素及其类似物的合成