MEASURE OF HUMAN RECEPTOR AND POST-RECEPTOR ACTIVITY

人类受体和受体后活性的测量

• 批准号: 3266444
• 负责人: DONALD C. HOOD
• 金额: $ 15.13万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3266444
• 关键词: cone cell; electroretinography; human subject; light adaptations; light intensity; mathematical model; model design /development; retina disorder; rod cell; visual photoreceptor

DESCRIPTION: (Investigator's abstract): The electroretinogram, ERG, is currently a valuable noninvasive technique available for diagnosing and following the course of retinal diseases. It has recently been shown that the initial portion of the human ERG can provide a quantitative measure of human rod receptor activity (Hood & Birch, 1990). These findings suggest that the ERG can be employed to answer fundamental questions about the functioning of both normal and abnormal human rod photoreceptors. Understanding rod receptor involvement in different diseases and in the normal process of light adaptation are among the specific aims of the proposed research. Our successful application of a quantitative model of the rod from the animal physiological literature encourages us to extent this work along two lines. First, we propose to measure cone a-waves and to compare them to models of cone receptor activity. In addition, alternative models of human cone receptor adaptation will be tested. Second, the long term goal of the proposed research is a quantitative model of the human ERG useful for testing hypotheses about normal and abnormal retinal activity. Thus, we propose to develop a model of the human ERG that encompasses the activity of the inner nuclear layer as well as the receptors.

描述：（研究者的摘要）：电子图，ERG是 目前是一种有价值的无创技术，可用于诊断和 跟随视网膜疾病。 最近已经证明 人类ERG的初始部分可以提供定量的衡量标准 人杆受体活性（Hood＆Birch，1990）。 这些发现表明 可以用ERG来回答有关 正常和异常人杆感光体的功能。 了解杆受体参与不同疾病和 正常的光适应过程是 拟议的研究。 我们成功地应用了定量模型的 动物生理文献的杆鼓励我们 这项工作沿两行。 首先，我们建议测量锥A波和 将它们与锥体受体活性模型进行比较。 此外， 将测试人锥体受体适应的替代模型。 其次，拟议的研究的长期目标是定量模型 人类ERG有助于测试正常和异常的假设 视网膜活动。 因此，我们建议开发人类ERG的模型 这包括内部核层的活性以及 受体。