Rosalind Franklin Institute - Next Generation Chemistry

罗莎琳德·富兰克林研究所 - 下一代化学

• 批准号: EP/V011359/1
• 负责人: Benjamin Davis
• 金额: $ 474.38万
• 依托单位: Rosalind Franklin Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV011359%2F1
• 关键词: Rosalind; Franklin; Institute; Next; Generation

The Life Sciences sector forms a key part of the UK economy: it employs over 220,000 people, contributes significantly to GDP and UK balance of trade, and is crucial for developing leading-edge treatments. It is underpinned by the UK's world-leading research base in the health and life sciences. Many key research breakthroughs are, in turn, enabled by advances in engineering and physical sciences (EPS) research - which provide ever more sophisticated instrumentation and methods to support the study of living organisms (from microbes to plants, animals and the human body) and biological processes (including both disease pathology and drug action). R&D across all parts of this ecosystem - from fundamental understanding to applied research to product development - is crucial for the delivery of long-term economic growth and continued advances in agriculture, food security, healthcare and public health. Historic models of innovation have often been linear, involving a degree of serendipity. Disruptive technologies and scientific breakthroughs will be accelerated if physical scientists, engineers, life scientists and industry work together, and at scale. This is the domain of the Rosalind Franklin Institute (RFI): with a focal point (Hub) at Harwell Science and Innovation Campus, linked to formal Spokes in leading HE ls across the UK, it will integrate complementary expertise from academia and industry to create a national centre of excellence for methods development at the convergence of the physical and life sciences.The diverse chemical control and editing of biological samples has profound potential well beyond current methods in traditional modes of Physical or Biological Sciences. This will ultimately complement and iteratively determine the value of other unifying goals of the Franklin such as Imaging. The ability to 'edit-characterize-and-image' could provide a grand challenge method for not only observing (imaging) biology but controlling (editing/treating) and hence understanding it in its post-translational state as a new mode of Medicine. The roadmap for Next Generation Chemistry (NGC) will unify several sub-projects that will span this spectrum of chemical control and understanding of biology.The NGC theme uses the rubric of:Construct (Synthetic Biology) -> Understand (Chemical Biology) -> Control (Chemical Medicine)In Construct, we aim to build and edit complex biological entities from the bottom-up.In Understand, we characterize and hence correlate built and modulated structures with function.In Control, we exploit this understanding to iteratively modulate and correct function with application primarily in Medicine and Biotechnology.

生命科学部门是英国经济的重要组成部分：它拥有超过220，000名员工，为GDP和英国贸易平衡做出了重大贡献，并且对开发尖端治疗至关重要。它以英国在健康和生命科学领域的世界领先研究基地为基础。许多关键的研究突破反过来又得益于工程和物理科学（EPS）研究的进步，这些研究提供了越来越复杂的仪器和方法，以支持对活生物体（从微生物到植物，动物和人体）和生物过程（包括疾病病理学和药物作用）的研究。这一生态系统的所有部分的研发-从基础知识到应用研究再到产品开发-对于实现长期经济增长以及农业、粮食安全、医疗保健和公共卫生的持续进步至关重要。历史上的创新模式往往是线性的，涉及一定程度的偶然性。如果物理科学家、工程师、生命科学家和工业界共同努力，并形成规模，颠覆性技术和科学突破将加速发展。这是罗莎琳德富兰克林研究所（RFI）的领域：在Harwell科学与创新校园有一个联络点（中心），与英国各地领先的HE LS的正式发言联系在一起，它将整合学术界和工业界的互补专业知识，创建一个国家卓越中心，在物理科学和生命科学的交汇点上开发方法。在物理或生物科学的传统模式远远超出目前的方法的深刻潜力。这将最终补充并迭代确定富兰克林的其他统一目标（如成像）的价值。“编辑-表征-和-成像”的能力可以提供一个巨大的挑战方法，不仅用于观察（成像）生物学，而且用于控制（编辑/治疗），从而将其理解为一种新的医学模式。下一代化学（NGC）的路线图将统一几个子项目，这些子项目将跨越化学控制和对生物学的理解。NGC主题使用以下标题：构建（合成生物学）->理解（化学生物学）->控制（化学医学）在构建中，我们的目标是自下而上构建和编辑复杂的生物实体。在理解中，我们表征并因此将构建和调制的结构与功能相关联。在控制中，我们利用这种理解来迭代调节和纠正功能，主要应用于医学和生物技术。