HYDROCARBONS AND DERIVATIVES AS BIOALKYLATING AGENTS

作为生物烷化剂的碳氢化合物及其衍生物

• 批准号: 3272553
• 负责人: GEORGE A OLAH
• 金额: $ 19.71万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3272553
• 关键词: acylation; alkanes; alkenes; alkylation; alkynes; carbopolycyclic compound; chemical carcinogen; chemical structure function; electron transport; food additives; free radicals; hydrocarbons; nitrosamines; nuclear magnetic resonance spectroscopy; nutrition related tag; sweetening agents; ultraviolet spectrometry

To continue study of biologically related alkylating agents. Investigations will include 1H, 13C and 17O nuclear magnetic resonance spectroscopic, as well as X-ray structural studies of carbocationic, as well as oxonium and carboxonium ion type alkylating agents. Novel ionic alkylating agents will be prepared and studied, including their formation mechanism. Electrophilic hydroxylation and epoxidation reactions of hydrocarbons will be continued under stable ion conditions. Alkylation reactions will also be studied under solid superacidic catalytic conditions capable of mimicking enzymatic systems. To prepare needed compounds and intermediates, continued study of new synthetic methods and reactions will also be continued.

继续研究生物学相关的烷基化剂。 调查 还包括1H，13C和17O核磁共振光谱镜 作为碳酸化的X射线结构研究，以及氧气和羧酸含量 离子型烷基化剂。 新颖的离子烷基化剂将准备好，并且 研究了，包括它们的形成机制。 亲电羟基化和 在稳定的离子下将继续碳氢化合物的环氧反应 状况。 还将在固体超酸催化下研究烷基化反应 能够模仿酶促系统的条件。 准备所需的化合物 和中间体，将继续研究新的合成方法和反应 也可以继续。