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MICROTUBULES AND AXOPLASM IN OLFACTORY NEURONS

MICROTUBULES AND AXOPLASM IN OLFACTORY NEURONS
嗅觉神经元中的微管和轴浆
批准号:
3272715
负责人:
PAUL R BURTON
金额:
$7.62万
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-06-01 至 1987-05-31

项目摘要

项目成果

PAUL R BURTON的其他基金

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相关文献

中文摘要
翻译
本研究的重点是青蛙嗅觉轴突的细胞骨架元件
英文摘要
This research focuses on cytoskeletal elements of frog olfactory axons, with emphasis on microtubules. The three-dimensional relationships between axoplasmic microtubules and neutrofiliments will be studied with the electron microscope. Cytochemical tests will be used on the ultrastructural level to localize ATPase activity in olfactory axons, and since some axons contain only neurofilaments and no microtubules, it will be of interest to see if these show ATPase activity distributed in the same manner as in axons containing both neurofilaments and microtubules. The substructure of isolated neurofilaments and neurofilaments in situ will be studied. Homogenates of olfactory nerve will be examined by SDS disc and slab gel electrophoresis to characterize the kinds of proteins present, particularly cytoskeletal proteins. Studies of the polarity of axonal microtubules will be continued, and these will involve the addition of soluble tubulin to preexisting microtubules as ribbon elements whose cross-sectional curvature indicates the polarity of the microtubules to which they are attached (ribbons either curve clockwise or counterclockwise). Finally, tracer studies will be used to test the hypothesis that bidirectional transport occurs in olfactory nerve axons, and these findings will be related to evidence regarding microtubule polarity.
期刊论文(9)
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会议论文
The distribution, relationships to other organelles, and calcium-sequestering ability of smooth endoplasmic reticulum in frog olfactory axons.
青蛙嗅觉轴突中光滑内质网的分布、与其他细胞器的关系以及钙隔离能力。
DOI: 10.1523/jneurosci.05-11-03047.1985
发表时间: 1985
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子: --
作者: [Burton,PR, Laveri,LA]
通讯作者: Laveri,LA
Correlative light and electron microscopy of dissociated immature rat testicular cells undergoing morphogenesis in vitro.
离解的未成熟大鼠睾丸细胞在体外进行形态发生的相关光学和电子显微镜。
DOI: --
发表时间: 1980
期刊: Journal of embryology and experimental morphology
影响因子: --
作者: [Erickson,LA, Davis,JC, Burton,PR, Snyder,J]
通讯作者: Snyder,J
DOI: 10.1083/jcb.99.2.520
发表时间: 1984-08
期刊: The Journal of cell biology
影响因子: --
作者: [Burton PR]
通讯作者: Burton PR
Effects of sodium salicylate on epithelial cells of the rectal mucosa of the rat: a light and electron microscopic study.
水杨酸钠对大鼠直肠粘膜上皮细胞的影响:光学和电子显微镜研究。
DOI: 10.1016/0024-3205(83)90656-2
发表时间: 1983
期刊: Life sciences
影响因子: 6.1
作者: [Sithigorngul,P, Burton,P, Nishihata,T, Caldwell,L]
通讯作者: Caldwell,L
PHILIPS CM10 TRANSMISSION ELECTRON MICROSCOPE
  • 批准号:
    3520267
  • 项目类别:
  • 资助金额:
    $18.8万
  • 财政年份:
    1989
  • 负责人:
    PAUL R BURTON
  • 依托单位:
CYTOSKELETON OF THE OLFACTORY NEURON
  • 批准号:
    3410737
  • 项目类别:
  • 资助金额:
    $8.97万
  • 财政年份:
    1987
  • 负责人:
    PAUL R BURTON
  • 依托单位:
CYTOSKELETON OF THE OLFACTORY NEURON
  • 批准号:
    3216888
  • 项目类别:
  • 资助金额:
    $8.54万
  • 财政年份:
    1987
  • 负责人:
    PAUL R BURTON
  • 依托单位:
CYTOSKELETON OF THE OLFACTORY NEURON
  • 批准号:
    3216889
  • 项目类别:
  • 资助金额:
    $8.26万
  • 财政年份:
    1987
  • 负责人:
    PAUL R BURTON
  • 依托单位:
海外基金