Heparan sulphate mimetics: Versatile tools for chemical biology

硫酸乙酰肝素模拟物：化学生物学的多功能工具

• 批准号: DP170104431
• 负责人: Prof Vito Ferro
• 金额: $ 30.48万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170104431
• 关键词: Heparan; sulphate; mimetics; Versatile; tools

This project aims to develop chemical tools to study heparan sulphate-binding proteins. Heparan sulphate is a complex polysaccharide that is ubiquitously expressed on mammalian cells and interacts with proteins to mediate numerous biological and pathological functions. These interactions are poorly understood. This project will use homogeneous, structurally defined compounds to study heparan sulphate and its binding partners in biology. This is expected to lead to a better, molecular-level understanding of these fundamental processes, and may have future applications in biotechnology and drug development.

该项目旨在开发化学工具来研究硫酸乙酰肝素结合蛋白。硫酸乙酰肝素是一种复杂的多糖，在哺乳动物细胞中普遍表达，并与蛋白质相互作用以介导多种生物学和病理学功能。人们对这些相互作用知之甚少。该项目将使用均质、结构明确的化合物来研究硫酸乙酰肝素及其生物学中的结合伙伴。预计这将导致对这些基本过程有更好的分子水平理解，并可能在生物技术和药物开发中具有未来的应用。