Opening Up Access to L-Sugars through a Synergy of Experiment and Theory

该项目旨在通过开发第一条广泛的L-糖合成路线来解决碳水化合物科学中的一个主要瓶颈。L-糖是许多生物学和商业上重要的分子的关键组分，但由于大多数L-糖昂贵或难以制造，因此对其功能作用的了解受到阻碍。该项目预计将通过合成和理论化学的创新组合开发快速的L-糖路线。预期成果包括显著提高获取L-糖基生物分子纯样品的能力，这是研究其生物功能所需的。预计将在疫苗、诊断和生物材料的开发方面产生重大效益。

This project aims to address a major bottleneck in the science of carbohydrates by developing the first broad-scope synthetic routes to L-sugars. L-sugars are critical components of many biologically and commercially significant molecules, but knowledge of their functional roles is impeded by the fact that most L-sugars are expensive or difficult to make. This project expects to develop expeditious routes to L-sugars via an innovative combination of synthetic and theoretical chemistry. Expected outcomes include a markedly increased capacity to access pure samples of L-sugar-based biomolecules, as needed for studying their biological functions. Significant benefits in the development of vaccines, diagnostics and biomaterials are anticipated.