NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS

这项研究旨在发现和开发新的不对称过程， 用于合成光学纯的有机物质，包括药物 和维生素。 重点放在不对称烯烃氧化过程， 还将研究刘易斯酸催化的反应。 所有 要研究的过程是金属催化或金属介导的， 涉及手性配体。 钛催化不对称环氧化反应机理的研究 相关工作将继续进行。 将作出特别努力， 获得了钛与各种金属的络合物的X射线晶体结构， 酒石酸盐衍生的配体。 这些机制研究的主要目的是 为了确保从这些新的催化剂和试剂中获得最大的利益， 有机合成领域。 具有C2和C3对称性的新型手性配体将被合成 并探讨了它们在不对称合成中的应用。 高效的不对称氧化路线，小手性双光子将是 寻求。 缩水甘油和甘油醛当量将是主要目标。

This research seeks to discover and develop new asymmetric processes for use in the synthesis of optically pure organic substances including drugs and vitamins. Emphasis is placed on asymmetric olefin oxidation processes, but asymmetric Lewis acid-catalyzed reactions will also be investigated. All of the processes to be studied are metal-catalyzed or metal-mediated, and all involve chiral ligands. Studies on the mechanism of the titanium-catalyzed asymmetric epoxidation and related processes will continue. A special effort will be made to obtain X-ray crystal structures of complexes of titanium with various tartrate-derived ligands. The primary aim of these mechanistic studies is to ensure maximum benefit from these new catalysts and reagents for the field of organic synthesis. New classes of chiral ligands having C2 and C3 symmetry will be synthesized and their applications in asymmetric synthesis investigated. Efficient asymmetric oxidation routes to small chiral synthons will be sought. Glycidol and glyceraldehyde equivalents will be primary targets.