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BIOLOGICAL STRUCTURAL STUDIES USING IMAGE PROCESSING

BIOLOGICAL STRUCTURAL STUDIES USING IMAGE PROCESSING
使用图像处理进行生物结构研究
批准号:
3274122
负责人:
PHILLIP ROSS SMITH
金额:
$17.96万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1979
资助国家:
美国
项目状态:
已结题
起止时间:
1979-07-01 至 1987-06-30

项目摘要

项目成果

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中文摘要
翻译
我们目前正在研究两种生物结构:晶体肌动蛋白片
英文摘要
We are currently studying two biological structures: crystalline actin sheets and the Sendai virus nucleocapsid. The purpose of the first project is to determine the molecular structure of actin to at least 10 A resolution. The crucial prerequisite for the realization of this project is the existence of highly ordered thin crystalline sheets of actin prepared by dialysis of G-actin against gadolinium ions. The specific aims are: To obtain 3-dimensional model of actin to 15 A resolution, determined from electron micrographs from tilted views of negatively stained preparations of crystalline actin sheets, and to find the orientation of the actin molecule within the actin filament by computationally aligning the model obtained from actin sheets with the model derived from paracrystals of actin filaments. The nucleocapsids of enveloped viruses are structures of major importance both as model-systems for the study of the synthesis and transport of proteins within cells, and in their own right as vital components of pathogenic viruses. The purpose of our project is to study the structure of the Sendai virus nucleocapsid. We aim to determine the geometrical packing of protein within the nucleocapsid and the location of the single RNA strand.
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CORE--COORDINATED COMPUTER FACILITY
CORE--COORDINATED COMPUTER FACILITY
CORE--COORDINATED COMPUTER FACILITY
CORE--COORDINATED COMPUTER FACILITY
  • 批准号:
    5206814
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    PHILLIP ROSS SMITH
  • 依托单位:
    --
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