Understanding T cell trafficking and function during antigenic interference

了解抗原干扰期间 T 细胞的运输和功能

• 批准号: DP240101665
• 负责人: Prof Katherine Kedzierska
• 金额: $ 54.6万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101665
• 关键词: Understanding; cell; trafficking; function; during

Science generally studies antigenic stimulation in isolation, by measuring immunity towards antigens derived from a single pathogen. However, as mammals can harbour more than one infection at any given time, we established a model of antigenic interference using different antigens derived from two unrelated pathogens, influenza A (IAV) and Semliki Forest virus (SFV). Our data show that prior exposure to either IAV or SFV greatly perturbs T cell dynamics. This proposal will study, at cellular and molecular levels, T cell trafficking, function and clonal distribution during antigenic interference, thus advance fundamental knowledge on T cell immunity during antigenic competition, and provide a new paradigm on how we research T cell immunity.

科学通常通过测量对来自单一病原体的抗原的免疫来孤立地研究抗原刺激。然而，由于哺乳动物可以在任何给定时间内携带不止一种感染，我们使用来自两种不相关病原体，甲型流感（IAV）和塞姆利基森林病毒（SFV）的不同抗原建立了抗原干扰模型。我们的数据表明，先前暴露于IAV或SFV极大地扰乱了T细胞动力学。本研究将在细胞和分子水平上研究抗原干扰过程中T细胞的运输、功能和克隆分布，从而进一步了解抗原竞争过程中T细胞免疫的基础知识，并为我们如何研究T细胞免疫提供一个新的范式。