Understanding and controlling viral escape in influenza

了解和控制流感病毒逃逸

• 批准号: nhmrc : 1008854
• 负责人: Prof Katherine Kedzierska
• 金额: $ 28.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-controlling-viral-escape-influenza/109348
• 关键词: Understanding; controlling; viral; escape; influenza

Introduction of a new influenza strain into human circulation leads to a rapid global spread of the virus (e.g. H1N1-09 pandemic) due to minimal antibody immunity. Established T-cell immunity towards conserved viral regions promotes rapid recovery. However, the protective immunity exerts pressure on influenza, leading to "escape" mutations. We will unravel how the viral mutants emerge and propose strategies for T cell-based protective immunity and vaccine design against influenza.

将一种新的流感毒株引入人体循环，由于抗体免疫力低下，导致病毒在全球迅速传播（例如H1N1-09大流行）。建立t细胞对保守病毒区域的免疫促进快速恢复。然而，保护性免疫对流感施加压力，导致“逃逸”突变。我们将揭示病毒突变体是如何出现的，并提出基于T细胞的保护性免疫和流感疫苗设计策略。