LARGE-RING AND HELICAL COMPLEXING AGENTS FOR METAL IONS

拟议研究的总体目标是开发新的 能够结合金属离子和运输的有机分子的类型 它们穿过细胞膜。一种金属络合剂，即 有一个坚硬的空腔，由六个- 成员环(吡啶和环己烷)，产生大的， 甜甜圈形状的结构。Torand合成方面的改进是 为了制备六正构烷基衍生物而提出的 堆积成柱状，形成盘状的中间相液晶。这 分子组织可能构成一种重要的战略 产生人造离子通道。还提出了合成和 大环“混合杂环”环的络合研究 这可能会对较大的碱金属表现出更大的选择性 离子，例如相对于钠的钾。新型络合剂 将作为离子载体在液膜中进行测试离子选择性 电极。不同金属离子络合物的结构 将由X射线结晶学和它们的稳定性来确定 将通过核磁共振和UV-Vis光谱进行测量。有选择性的 离子载体可以用来构建离子选择电极，以 血清和尿液中金属离子的临床分析

The general objective of the proposed research is to develop new types of organic molecules that can bind metal ions and transport them across membranes. One type of metal complexing agent, the torands, has a rigid cavity that is formed by the fusion of six- membered rings (pyridine and cyclohexane), resulting in a large, doughnut-shaped structure. Improvements in torand synthesis are proposed in order to prepare hexa-n-alkyl derivatives that may stack in columns, forming discotic mesophase liquid crystals. This molecular organization may constitute an important strategy for producing artificial ion channels. Also proposed are synthesis and complexation studies of larger ring "mixed heterocycle" torands that may display greater selectivity towards larger alkali metal ions, e.g. potassium relative to sodium. The new complexing agents will be tested as ionophores in liquid membrane ion-selective electrodes. The structures of complexes with various metal ions will be determined by X-ray crystallography and their stabilities will be measured by NMR and UV-VIS spectroscopy. Selective ionophores may be used to construct ion-selective electrodes for clinical analysis of metal ions in blood serum and urine.