LARGE-RING AND HELICAL COMPLEXING AGENTS FOR METAL IONS

本提案的目的是合成一系列多环有机 具有金属离子的氮结合位点的分子，并测试它们的 离子选择性 选择目标系统是因为它们的刚性， 预期的尺寸选择性形成包合物，这将是 可溶于有机溶剂。 潜在的应用包括离子选择性 电极、膜金属分离和生物膜离子模拟 渠道 大环（18 ~ 24元）大环化合物的合成 包括酮烯醇化物的氧化以提供低聚1，4-二酮， 其可以转化为呋喃或吡咯。 目标大环化合物 含有吡啶结合位点的化合物通过缩合 合适的芳族胺与酮酯，然后芳构化 生成的吡啶酮环。 六齿和七齿螺旋配体是 还提出了，以及螺旋聚合物， 细胞膜上的通道

The object of this proposal is to synthesize a series of polycyclic organic molecules bearing nitrogen binding sites for metal ions and to test their ion selectivity. The target systems were chosen for their rigidity and expected size-selectivity in forming inclusion complexes which will be soluble in organic solvents. Potential applications include ion-selective electrodes, membrane metal separation and modeling of biomembrane ion channels. The proposed syntheses of large ring (18 to 24-membered) macrocycles involve oxidation of ketone enolates to provide oligomeric 1,4-diketones, which may be converted to furans or pyrroles. Target macrocycles containing pyridine binding sites are to be synthesized by condensing appropriate aromatic amines with ketoesters, followed by aromatization of the resulting pyridone rings. Six and seven-dentate helical ligands are also proposed, as well as helical polymers which may form ion conducting channels in membranes.