CYCLIZATION METHODS FOR NATURAL PRODUCT SYNTHESIS

天然产物合成的环化方法

• 批准号: 3277705
• 负责人: A RICHARD CHAMBERLIN
• 金额: $ 12.04万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-02-01 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3277705
• 关键词: alkaloids; antihypertensive agents; antiinflammatory agents; antineoplastics; antispasmodic agents; chemical carcinogen; chemical synthesis; cyclic compound; cyclization; drug design /synthesis /production; indolizines; lactones; local anesthetics; monocrotaline; neuromuscular blocking agents; polyenes; quinolizine; reserpine; yohimbine

The principle objective of this proposal is to develop efficient new procedures for the stereoselective synthesis of a variety of biologically active molecules. A major focus is to be on new methods of ring formation, a basic reaction that is ubiquitous in natural products synthesis. New aspects of cationic, radical, and carbanionic cyclizations will be studied, with particular emphasis on the stereoselectivity of these processes. Findings will then be applied to the synthesis of alkaloids, steroids, and other biologically active molecules.

该提议的主要目的是开发有效的新 立体选择性合成各种生物学的程序 活性分子。 主要重点是将环形形成的新方法， 在天然产物合成中无处不在的基本反应。 新的 将研究阳离子，激进和氨基离子离子循环的各个方面， 特别强调了这些过程的立体选择性。 然后，发现将应用于生物碱，类固醇和 其他具有生物活性的分子。