The neural substrates of a false fear memory in rats

该项目旨在使用实验室啮齿动物来研究对厌恶经历的错误记忆(虚假恐惧记忆)。记忆并不总是对一次经历的忠实记录。特别是在情绪化的情况下，人们可能会以从未发生过的方式记住事件。这个项目研究了虚假恐惧记忆是如何形成的，以及这种记忆在杏仁核和海马体中的神经基础。这些发现应该会促进人们对大脑如何表示事件、提取的事件表示如何与当前事件的各个方面相关联、以及学习提取的但不存在的事件如何模糊幻想和现实之间的界限的认识。

This project aims to use laboratory rodents to study false memory of an aversive experience (false fear memory). Memory is not always a faithful record of an experience. Particularly under emotional circumstances, events can be remembered in ways they never occurred. This project studies how a false fear memory forms, and the neural substrates of this memory in the amygdala and hippocampus. The findings should advance knowledge about how the brain represents events, how retrieved event representations associate with aspects of present events, and how learning about retrieved-but-absent events blurs the line between fantasy and reality.