The neural substrates of a false fear memory in rats

大鼠虚假恐惧记忆的神经基础

• 批准号: DP170103952
• 负责人: Dr Nathan Holmes
• 金额: $ 29.84万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170103952
• 关键词: neural; substrates; false; fear; memory

This project aims to use laboratory rodents to study false memory of an aversive experience (false fear memory). Memory is not always a faithful record of an experience. Particularly under emotional circumstances, events can be remembered in ways they never occurred. This project studies how a false fear memory forms, and the neural substrates of this memory in the amygdala and hippocampus. The findings should advance knowledge about how the brain represents events, how retrieved event representations associate with aspects of present events, and how learning about retrieved-but-absent events blurs the line between fantasy and reality.

本项目旨在利用实验室啮齿类动物研究厌恶经历的虚假记忆（虚假恐惧记忆）。记忆并不总是对经历的忠实记录。特别是在情绪激动的情况下，事情可能会以从未发生过的方式被记住。本项目研究虚假恐惧记忆是如何形成的，以及这种记忆在杏仁核和海马体中的神经基质。这些发现将有助于我们进一步了解大脑是如何表征事件的，被检索到的事件表征是如何与当前事件的各个方面相关联的，以及对被检索但不存在的事件的学习是如何模糊了幻想与现实之间的界限的。