Extinction of fears based on learned sources of danger

这个项目旨在促进我们对恐惧记忆是如何在哺乳动物的大脑中编码和存储的理解。它试图通过使用动物模型来实现这一目标，即大鼠的二阶恐惧条件反射。它在提供不同类型恐惧记忆的首次系统评估方面具有重要意义，例如，在与先天(例如，涉及窒息或疼痛)或后天危险来源(例如，受到枪支威胁)相遇期间形成的那些恐惧记忆。预期结果包括关于如何控制或抑制不同类型的恐惧记忆的新信息。这些信息对于发展全面的恐惧理论和改善恐惧的各种障碍的调节策略是必要的。

This project aims to advance our understanding of how fear memories are encoded and stored in the mammalian brain. It seeks to achieve this aim through the use of an animal model, second-order fear conditioning in rats. It is significant in providing the first systematic assessment of different types of fear memories, such as those that form during encounters with innate (e.g., involving suffocation or pain) or learned sources of danger (e.g., being threatened with a gun). The expected outcomes include new information regarding how different types of fear memories can be controlled or inhibited. This information is needed for the development of a comprehensive theory of fear, and improved fear regulation strategies in its various disorders.