Extinction of fears based on learned sources of danger

根据已知的危险来源消除恐惧

• 批准号: DP200102969
• 负责人: Dr Nathan Holmes
• 金额: $ 28.58万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-01-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102969
• 关键词: Extinction; fears; based; learned; sources

This project aims to advance our understanding of how fear memories are encoded and stored in the mammalian brain. It seeks to achieve this aim through the use of an animal model, second-order fear conditioning in rats. It is significant in providing the first systematic assessment of different types of fear memories, such as those that form during encounters with innate (e.g., involving suffocation or pain) or learned sources of danger (e.g., being threatened with a gun). The expected outcomes include new information regarding how different types of fear memories can be controlled or inhibited. This information is needed for the development of a comprehensive theory of fear, and improved fear regulation strategies in its various disorders.

这个项目旨在促进我们对恐惧记忆如何在哺乳动物大脑中编码和存储的理解。它试图通过使用动物模型来实现这一目标，老鼠的二阶恐惧条件反射。对于不同类型的恐惧记忆，比如在遭遇先天的（例如，涉及窒息或疼痛）或习得的危险源（例如，受到枪的威胁）时形成的恐惧记忆，它提供了第一次系统的评估，这是很重要的。预期的结果包括关于如何控制或抑制不同类型的恐惧记忆的新信息。这一信息是需要一个全面的理论的发展的恐惧，并在其各种障碍的改进恐惧调节策略。