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NMR STUDIES OF METABOLIC PATHWAYS IN VIVO AND IN VITRO

NMR STUDIES OF METABOLIC PATHWAYS IN VIVO AND IN VITRO
体内和体外代谢途径的 NMR 研究
批准号：
3281595
负责人：
ALASTAIR I SCOTT
金额：
$19.22万
依托单位：
TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
项目状态：
已结题
起止时间：
1983-03-01 至 1988-02-29
来源：
https://reporter.nih.gov/project-details/3281595
关键词：
Fungi Krebs' cycle bacteria biotransformation cell free system cephalosporins chemical reaction chemical synthesis cholesterol chymotrypsin clinical biomedical equipment cryoscience eicosanoid metabolism erythrocytes fatty acid biosynthesis fatty acid synthase fermentation fibroblasts gluconeogenesis glycolysis human tissue luciferin monooxygenase metalloenzyme methionine methylmalonyl coA epimerase neoplastic cell noninvasive diagnosis nuclear magnetic resonance spectroscopy nutrition related tag o aminobenzoate pancreatic ribonuclease papain penicillins plants prostaglandin endoperoxide synthase purine /pyrimidine metabolism radiopharmacology squalene stable isotope diagnosis steroid biosynthesis tetracyclines tissue /cell culture trypsin vitamin B12 compound vitamin biosynthesis

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中文摘要
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英文摘要
Development of techniques using wide-bore, high-field (300-500 MHz), high-resolution NMR spectroscopy to study metabolic processes in living systems and in vitro will be undertaken. The use of multiply labeled substrates (13C, 15N, 2H) prepared by regiospecific synthesis will be of value in assigning chemical shifts to unknown and short-lived species. It is proposed to use cryoenzymology and flow cells to study the flux of carbon, hydrogen and nitrogen in biochemical reactions, to identify hitherto undetected species and to devise non-invasive methods for the analysis of microgram quantities of biologically important molecules during metabolism in mammalian, bacterial and plant cells, as well as whole, perfused organs and insects.
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