GLUCONEOGENESIS & KREBS CYCLE FLUXES IN HUMANS

糖异生

• 批准号: 7357878
• 负责人: Craig R Malloy
• 金额: $ 11.74万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357878
• 关键词: Krebs' cycle; carbon; conditioning; fasting; gluconeogenesis; glucose; glycerol; glycogen; glycogenolysis; human; lipids; measurement; noninsulin dependent diabetes mellitus; plasma; striated muscles; urine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A basic question in the pathogenesis of type 2 diabetes (T2DM) is the mechanism of excessive glucose production. In recent years multiple studies have assessed gluconeogenesis (the sum of glucose originating from carbon skeletons in the TCA cycle and glycerol) versus glycogenolysis after an overnight fast. The goal of this project is to refine the technologies and concepts developed in Cores 1 and 2 for routine applications in humans. In addition to continuing our work with conventional 2H and 13C NMR for analysis of plasma and urine under various metabolic conditions, we have initiated studies at 3T and 7T for measurement of intramyocellular lipids and glycogen content in skeletal muscle of humans.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。2型糖尿病（T2 DM）发病机制中的一个基本问题是葡萄糖过度产生的机制。近年来，多项研究评估了禁食过夜后的糖原合成（TCA循环中源自碳骨架的葡萄糖和甘油的总和）与糖原分解。该项目的目标是完善核心1和2中开发的技术和概念，用于人类的常规应用。除了继续我们的工作与传统的2 H和13 C NMR分析血浆和尿液在各种代谢条件下，我们已经开始在3 T和7 T的研究，用于测量肌细胞内脂质和糖原含量在骨骼肌的人。