BIO-ACTIVE COMPOUNDS VIA AQUEOUS ORGANIC CHEMISTRY

通过水性有机化学制备生物活性化合物

• 批准号: 3283528
• 负责人: PAUL A GRIECO
• 金额: $ 21.95万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3283528
• 关键词: Diels Alder reaction; N acetylneuraminate; biological products; chemical reaction; chemical structure function; diene; drug design /synthesis /production; hydroxylamine; macrolide antibiotics; organic chemicals; physostigmine; stereochemistry; steroid glycoside aglycone; water solubility; water solution

The objectives of the present proposal are (1) the total synthesis of the aglycone of tylosin, tylonolide, and (2) completion of the total synthesis of the ionophore A23187.

本提案的目标是：(1)全面综合 泰乐菌素的苷元，以及(2)完成泰乐菌素的全合成 离子浮子A23187。