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TUMOR INHIBITORS AND RELATED SUBSTANCES

TUMOR INHIBITORS AND RELATED SUBSTANCES
肿瘤抑制剂及相关物质
批准号：
2087818
负责人：
PAUL A GRIECO
金额：
$29.98万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1980
资助国家：
美国
项目状态：
已结题
起止时间：
1980-06-01 至 1997-03-31
来源：
https://reporter.nih.gov/project-details/2087818
关键词：
antineoplastics cardenolides cardiac glycoside aglycone chemical structure function drug adverse effect drug design /synthesis /production drug metabolism drug screening /evaluation medicinal plants neoplasm /cancer pharmacology plant extracts

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中文摘要
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英文摘要
This proposal focuses on the synthesis of antineoplastic agents. In the quassinoid area major emphasis will be placed on completing syntheses of quassimarin, bruceantin, and glaucarubinone. As a result of the lower toxicity in in vivo systems of 4beta-hydroxy withanolide E relative to cardenolides and bufadienolides, a synthetic program centered around 4beta-hydroxy withanolide E has been initiated in an effort to uncover an analog possessing a reasonable therapeutic index. Part III of this proposal focuses on a convergent total synthesis of the potent cytotoxic cyclodepsidpeptide, jaspamide. In addition a number of analogs will be prepared in order to examine the structural requirements for biological activity.
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NEW PROTEOMIC REAGENT SYNTHESIS
NEW PROTEOMIC REAGENT SYNTHESIS
NEW PROTEOMIC REAGENT SYNTHESIS
400 MHZ NMR INSTRUMENT
  • 批准号：
    3519868
  • 项目类别：
  • 资助金额：
    $30.0万
  • 财政年份：
    1988
  • 负责人：
    PAUL A GRIECO
  • 依托单位：
    TRUSTEES OF INDIANA UNIVERSITY
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