BRIDGEHEAD CARBOCATIONS IN SYNTHESIS

本提案的目的是确定以下内容的范围和限制 有机合成中的桥头碳正离子。多环化合物的合成 含有双环[2.2.2]辛烷、双环[3.2.1]辛烷和 双环[3.3.1]将完成正庚烷亚基。生物学上的 重要分子，如APHIICOIN(抗癌剂、抗病毒 试剂)将被合成。因为桥头碳离子一直没有被 以前在合成中使用的，这项建议应该提供新的 和高效的合成途径。

The aim of this proposal is to identify the scope and limitations of bridgehead carbocations in organic synthesis. The synthesis of polycyclic natural products containing bicyclo[2.2.2]octane, bicyclo[3.2.1]octane and bicyclo[3.3.1]nonane subunits will be accomplished. Biologically significant molecules such as aphidicolin (anticancer agent, antiviral agent) will be synthesized. Since bridgehead carbocations have not been previously employed in synthesis, this proposal should make available new and efficient synthetic pathways.