BRIDGEHEAD CARBOCATIONS IN SYNTHESIS

本提案的目的是确定 有机合成中的桥头碳正离子。 多环的合成 含有双环[2.2.2]辛烷、双环[3.2.1]辛烷和 双环[3.3.1]壬烷亚基将被完成。 生物 重要分子如阿非迪霉素（抗癌剂、抗病毒剂 将被合成。 由于桥头的碳正离子还没有 以前在合成中使用，这一建议应提供新的 和高效的合成途径。

The aim of this proposal is to identify the scope and limitations of bridgehead carbocations in organic synthesis. The synthesis of polycyclic natural products containing bicyclo[2.2.2]octane, bicyclo[3.2.1]octane and bicyclo[3.3.1]nonane subunits will be accomplished. Biologically significant molecules such as aphidicolin (anticancer agent, antiviral agent) will be synthesized. Since bridgehead carbocations have not been previously employed in synthesis, this proposal should make available new and efficient synthetic pathways.