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DYNAMICS OF ACTIN FILAMENTS IN NERVE GROWTH

DYNAMICS OF ACTIN FILAMENTS IN NERVE GROWTH
肌动蛋白丝在神经生长中的动力学
批准号：
3287279
负责人：
JAMES R BAMBURG
金额：
$13.76万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-12-01 至 1989-11-30
来源：
https://reporter.nih.gov/project-details/3287279
关键词：
adenosinetriphosphatase affinity chromatography autoradiography brain brain metabolism cell growth regulation cell population study circular dichroism conformation density gradient ultracentrifugation electrofocusing electron microscopy gel electrophoresis glia ions local anesthetics messenger RNA neuropharmacology neurotrophic factors stoichiometry tissue /cell culture ultraviolet spectrometry wheat

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英文摘要
Using an assay for G-actin based on its ability to inhibit the hydrolytic activity of DNAase, we have isolated a protein from brain which actively promotes the depolymerization of F-actin in solution. This protein will now be further characterized as to its molecular weight, isoelectric point, amino acid composition and its ability to interact with F-actin alone and in the presence of associated proteins such as tropomyosin. A modification of the DNAase inhibition assay has been developed which permits the assay of G-actin in the presence of F-actin under conditions where no exchange between the two actin pools occurs. This assay will be applied to the measurement of G and F-actin concentrations in synchronized CHO cells during the cell cycle.
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Role of cofilin pathology in mouse models of cognitive impairment
  • 批准号：
    8664331
  • 项目类别：
  • 资助金额：
    $18.59万
  • 财政年份：
    2013
  • 负责人：
    JAMES R BAMBURG
  • 依托单位：
    COLORADO STATE UNIVERSITY
Role of cofilin pathology in mouse models of cognitive impairment
  • 批准号：
    8486049
  • 项目类别：
  • 资助金额：
    $22.3万
  • 财政年份：
    2013
  • 负责人：
    JAMES R BAMBURG
  • 依托单位：
    COLORADO STATE UNIVERSITY
ISOLATION AND CHARACTERIZATION OF CYTOPLASMIC COFILIN-ACTIN RODS
  • 批准号：
    8171304
  • 项目类别：
  • 资助金额：
    $0.08万
  • 财政年份：
    2010
  • 负责人：
    JAMES R BAMBURG
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Training in Synaptic Neurobiology
  • 批准号：
    6768597
  • 项目类别：
  • 资助金额：
    $25.73万
  • 财政年份：
    2002
  • 负责人：
    JAMES R BAMBURG
  • 依托单位：
    COLORADO STATE UNIVERSITY
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