课题基金 / 基金详情

MECHANISMS OF SUPEROXIDE DISMUTASES

MECHANISMS OF SUPEROXIDE DISMUTASES
超氧化物歧化酶的机制
批准号：
3287502
负责人：
JAMES A FEE
金额：
$17.77万
依托单位：
UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
项目状态：
已结题
起止时间：
1984-12-01 至 1989-11-30
来源：
https://reporter.nih.gov/project-details/3287502
关键词：
Escherichia coli X ray crystallography catalyst cell biology cell growth regulation chemical reaction copper genetic manipulation heavy metals hydrogen hydrogen peroxide iron manganese metalloproteins respiratory oxygen superoxide dismutase zinc

项目摘要

项目成果

JAMES A FEE的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The principal objective of this project is to understand in detail the mechanisms whereby Zn/Cu, Fe, and Mn containing superoxide dismutases catalyze the reaction, 202-+2H+ is greater than H2O2+O2. Our procedures involve the application of a variety of physical techniques ranging from x-ray crystallography to obtain three-dimensional structures to spectroscopic measuements to characterize the electronic structure of these metalloproteins. Kinetic mechanisms are being explored using a stopped-flow spectrophotometer specially designed for the study of superoxide in aqueous media. Simple recombinant DNA technqiues are being applied to the study of enzyme mechanisms and physiological function of these proteins.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HIGH-RESOLUTION CRYSTALLOGRAPHIC STUDIES OF TWO RESPIRATORY PROTEINS FROM T THE
  • 批准号：
    8362154
  • 项目类别：
  • 资助金额：
    $0.19万
  • 财政年份：
    2011
  • 负责人：
    JAMES A FEE
  • 依托单位：
    STANFORD UNIVERSITY
HIGH-RESOLUTION CRYSTALLOGRAPHIC STUDIES OF TWO RESPIRATORY PROTEINS FROM T THE
  • 批准号：
    8170102
  • 项目类别：
  • 资助金额：
    $0.37万
  • 财政年份：
    2010
  • 负责人：
    JAMES A FEE
  • 依托单位：
    STANFORD UNIVERSITY
HIGH-RESOLUTION CRYSTALLOGRAPHIC STUDIES OF TWO RESPIRATORY PROTEINS FROM T THE
  • 批准号：
    7954429
  • 项目类别：
  • 资助金额：
    $0.93万
  • 财政年份：
    2009
  • 负责人：
    JAMES A FEE
  • 依托单位：
    STANFORD UNIVERSITY
HIGH RESOLUTION CRYSTALLOGRAPHIC STUDIES OF RESPIRATORY PROTEINS FROM T THERMOP
  • 批准号：
    7954159
  • 项目类别：
  • 资助金额：
    $0.02万
  • 财政年份：
    2009
  • 负责人：
    JAMES A FEE
  • 依托单位：
    STANFORD UNIVERSITY
海外基金