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MOLECULAR BIOLOGY OF MITOSIS IN ASPERGILLUS

MOLECULAR BIOLOGY OF MITOSIS IN ASPERGILLUS
曲霉有丝分裂的分子生物学
批准号：
3286173
负责人：
N. R MORRIS
金额：
$15.12万
依托单位：
UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
项目状态：
已结题
起止时间：
1985-08-01 至 1990-07-31
来源：
https://reporter.nih.gov/project-details/3286173
关键词：
Aspergillus cell nucleus cytogenetics endonuclease enzyme linked immunosorbent assay fluorescence microscopy fungal genetics gene complementation gene interaction gene mutation genetic library genetic manipulation genetic mapping genetic translation immunoprecipitation karyotype messenger RNA molecular biology molecular cloning molecular genetics nucleic acid hybridization nucleic acid sequence temperature sensitive mutant

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中文摘要
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英文摘要
An understanding of mitosis, its regulation and its mechanics is central to many areas of medicine having to do with cell growth and division, e.g., cancer, embryological development and human genetics. The objective of this project is a better understanding of the mechanics and regulation of nuclear division. The immediate goal is to identify and characterize the products of specific genes involved in nuclear division by using DNA mediated transformation to complement specific mitotic mutations in Aspergillus nidulans. Genes will be cloned, sequenced and their products characterized by hybrid selection and translation of complementary messenger RNA's. Antibodies to the protein products of these genes will be prepared and used to localize the gene products in cells.
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