SYNTHETIC AND PHYSICAL STUDIES OF ANTICANCER AGENTS

抗癌剂的合成和物理研究

• 批准号: 3291396
• 负责人: JAMES C MARTIN
• 金额: $ 13.94万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3291396
• 关键词: chemical cleavage; chemical hydration; chemical structure; clathrate; drug design /synthesis /production; drug screening /evaluation; epoxides; heterocyclic compounds; leukemia; oxidation; sulfurous heterocyclic compound

Syntheses of pentacoordinate sulfure species have been extended to sulfurane imines. The chemistry of these novel species will be explored. Simpler examples of pentavalent carbon species will be sought. The synthesis of an ortho-bridged triarylcarbinol with bridge sulfur atoms will be pursued using new synthetic methodology involving the directed ortho-lithiation of arenesulfonic acids.

五配位硫化物的合成已扩展到硫烷