课题基金 / 基金详情

CONTROL OF LUTEINIZING HORMONE BIOSYNTHESIS

CONTROL OF LUTEINIZING HORMONE BIOSYNTHESIS
黄体生成素生物合成的控制
批准号：
3311142
负责人：
GARY L JACKSON
金额：
$11.63万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
项目状态：
已结题
起止时间：
1976-05-01 至 1987-02-28
来源：
https://reporter.nih.gov/project-details/3311142
关键词：
carbohydrate structure chemical group cyclic nucleoside monophosphate estrogens estrus glucose metabolism glycosyltransferase hormone regulation /control mechanism luteinizing hormone peptide hormone biosynthesis pituitary gland radioimmunoassay radionuclide double label scintillation counter secretion sex hormones

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中文摘要
翻译
我们将通过监测放射性标记的 前体转化为LH。 新合成 将通过特异性抗体免疫沉淀分离LH。 的 雌激素和孕激素对LH生物合成的影响将在 这系统. 此外，合成和释放之间的关系将是 研究试图确定这两个分泌步骤是否紧密相关， 耦合。 通过比较LH，监测GnRH对LH大小的影响。 在存在GnRH的情况下合成的与在不存在GnRH的情况下合成的相比， 促性腺激素释放激素
英文摘要
We will investigate biosynthesis by monitoring incorporation of radiolabelled precursors into LH by dispersed rat anterior pituitary cells. Newly synthesized LH will be isolated by immunoprecipitation with specific antibodies. The effects of estrogen and progesterone on LH biosynthesis will be determined in this system. Also the relationships between synthesis and release will be studied in an attempt to determine if these two steps of secretion are tightly coupled. The effect of GnRH on the size of LH will be monitored by comparing LH synthesized in the presence of GnRH with that synthesized in the absence of GnRH.
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会议论文
NEURAL PEPTIDES AND LH RELEASE IN THE MALE
CONTROL OF LHRH SECRETION IN THE MALE
CONTROL OF LHRH SECRETION IN THE MALE
CONTROL OF LHRH SECRETION IN THE MALE