CONTROL OF LHRH SECRETION IN THE MALE

总体目标是定义性腺类固醇的基本影响，即 性腺类固醇激素类型的影响以及季节性激素的交互作用 性腺激素对男性LHRH和LH型的影响 拉姆当模特。 具体目标是： 1.明确季节对LHRH和LH脉搏的影响 关系并检验LHRH的无效假设 分泌模式和LHRH-LH关系不随 赛季到了。LHRH和LH脉冲参数将分3个阶段进行分析 一年一度的生殖周期。 2.检验主要性腺类固醇激素的无效假设 (睾酮和雌激素)不改变LHRH的脉搏 男性体内的参数。常量的影响 单独的睾酮和雌激素的生理浓度 并结合，对LHRH和LHRH的脉冲参数进行了确定。 3.要检验这样一种假设，即间歇性分娩 睾酮在改变LHRH和黄体生成素脉搏方面更有效 参数，而不是恒定的传递。这两种模式的效果 交货率将进行比较。 4.检验睾丸激素模式的假设 脉冲影响促黄体生成素和促黄体生成素脉冲的模式。 最初，对称、均匀间隔的T脉冲的影响将是 与对称的、不均匀间隔的T脉冲的效果相比。

The overall aims are to define the basic effects of gonadal steroids, the effects of patterns of gonadal steroids, and the interactions of seasonal effects and gonadal steroids on LHRH and LH patterns in the male using the ram as a model. The specific aims are: 1. To define the effect of season on LHRH and LH pulse relationships and test the null hypotheses that LHRH secretory patterns and LHRH-LH relationships do not change with season. LHRH and LH pulse parameters will be analyzed at 3 phases of the annual reproductive cycle. 2. To test the null hypothesis that the major gonadal steroids (testosterone and estrogen) do not alter LHRH pulse parameters in the male. The effects of constant physiological concentrations of testosterone and estrogen, alone and combined, on LH and LHRH pulse parameters will be determined. 3. To test the hypothesis that episodic delivery of testosterone is more effective in altering LHRH and LH pulse parameters than is constant delivery. The effects of the two modes of delivery will be compared. 4. To test the hypothesis that the pattern of testosterone pulses affects the patterns of LHRH and LH pulses. Initially, the effects of symmetrical, evenly spaced T pulses will be compared with the effects of symmetrical, unevenly spaced T pulses.