CONTROL OF LHRH SECRETION IN THE MALE

男性 LHRH 分泌的控制

• 批准号: 3329122
• 负责人: GARY L JACKSON
• 金额: $ 8.27万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3329122
• 关键词: drug administration rate /duration; drug delivery systems; estrogens; gonads; hormone regulation /control mechanism; hypothalamic pituitary axis; luteinizing hormone; male; male castration; male reproductive system; pituitary gonadal axis; radioimmunoassay; sex cycle; sheep; testosterone

The overall aims are to define the basic effects of gonadal steroids, the effects of patterns of gonadal steroids, and the interactions of seasonal effects and gonadal steroids on LHRH and LH patterns in the male using the ram as a model. The specific aims are: 1. To define the effect of season on LHRH and LH pulse relationships and test the null hypotheses that LHRH secretory patterns and LHRH-LH relationships do not change with season. LHRH and LH pulse parameters will be analyzed at 3 phases of the annual reproductive cycle. 2. To test the null hypothesis that the major gonadal steroids (testosterone and estrogen) do not alter LHRH pulse parameters in the male. The effects of constant physiological concentrations of testosterone and estrogen, alone and combined, on LH and LHRH pulse parameters will be determined. 3. To test the hypothesis that episodic delivery of testosterone is more effective in altering LHRH and LH pulse parameters than is constant delivery. The effects of the two modes of delivery will be compared. 4. To test the hypothesis that the pattern of testosterone pulses affects the patterns of LHRH and LH pulses. Initially, the effects of symmetrical, evenly spaced T pulses will be compared with the effects of symmetrical, unevenly spaced T pulses.

总体目标是确定性腺类固醇的基本作用， 性腺类固醇模式的影响，以及季节性激素的相互作用， 影响和性腺类固醇激素对LHRH和LH模式的男性使用 作为一个模型的RAM。 具体目标是： 1. 确定季节对LHRH和LH脉冲的影响 关系，并检验LHRH 分泌模式和LHRH-LH关系不变 与 赛季 分析LHRH和LH脉冲参数 分三个阶段 一年一次的繁殖周期。 2. 为了检验主要的性腺类固醇 （睾酮和雌激素）不改变LHRH脉冲 男性的参数。 常数的影响 睾酮和雌激素的生理浓度， 单独 并结合LH和LHRH脉冲参数， 测定 3.为了验证这一假设， 睾酮在改变LHRH和LH方面更有效 脉冲 参数比恒定的交付。 的影响 两种模式 交付将进行比较。 4. 为了验证睾丸激素的模式 脉冲影响LHRH和LH脉冲的模式。 最初，对称的，均匀间隔的T脉冲的影响 将 与对称的、不均匀的 间隔T脉冲。