CO-ADAPT: Adaptive management of endemic coinfections in ruminant livestock under climate change

家畜通常被许多不同种类的寄生虫(称为混合感染)感染，但寄生虫控制通常集中在一种或一组有限的相关物种上。COADAPT的核心目标是通过提高预测、测量和定位田间混合感染的能力来实现影响，并为开发和应用提供工具--增强英国养殖业的竞争力和可持续性，并加强预测生物学和寄生虫控制数字决策支持工具方面的国际领先能力。我们把重点放在放牧反刍动物的寄生虫和胃肠道混合感染上，因为它们普遍存在，经常限制产量，而且经常不适当地针对它们。感染季节性模式的变化和抗寄生虫药物耐药性的增加对今后管理对生产、排放和动物福利的影响的能力造成了重大限制。关键的挑战是能够适应性地管理混合感染，根据感染状况和影响准确地校准干预措施，使用有限的化学投入来获得最佳反应。这将需要与当前的风险保持一致，并有效支持农场决策。

Livestock are commonly infected by many different species of parasite (termed coinfections), and yet parasite control generally focuses on one species or a limited group of related species. The core goal of COADAPT is to achieve impact by improving ability to predict, measure and target coinfections in the field, and supply tools for exploitation and application - to enhance the competitiveness and sustainability of the UK farming industry and to reinforce internationally leading capabilities in predictive biology and digital decision support tools for parasite control. We focus on parasitic and gastrointestinal coinfections in grazing ruminants because they are universally common, frequently production-limiting, and often inappropriately targeted. Changes in seasonal patterns of infection and increasing antiparasitic drug resistance impose major limitations on future ability to manage impacts on production, emissions and animal welfare. The key challenge is to be able to manage coinfections adaptively, calibrating interventions accurately to infection status and impact, using limited chemical inputs to obtain the best response. This will require alignment with prevailing risks, and effective support of on-farm decisions.