Surveillance of the mechanisms controlling proteome foldedness

控制蛋白质组折叠机制的监测

• 批准号: DP170103093
• 负责人: Prof Daniel Hatters
• 金额: $ 32.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170103093
• 关键词: Surveillance; mechanisms; controlling; proteome; foldedness

This project aims to measure how cells keep the proteome folded. Cells have extensive quality control networks to govern synthesis, folding and transport of every protein but the buffering capacity of this system is not definable. This capacity is needed to understand how problems arise in managing proteome foldedness, a central feature of human diseases and biotechnology and synthetic biology applications that need cell-based production of engineered proteins such as hormones and antibodies. The outcomes are expected to provide basic knowledge of this fundamental process and provide biosensors and screening methods for use in health and biotechnology industries.

该项目旨在测量细胞如何保持蛋白质组折叠。细胞有广泛的质量控制网络来管理每种蛋白质的合成、折叠和运输，但这个系统的缓冲能力还不确定。需要这种能力来理解在管理蛋白质组折叠方面如何出现问题，蛋白质组折叠是人类疾病和生物技术和合成生物学应用的一个核心特征，需要基于细胞生产工程蛋白质，如激素和抗体。预计结果将提供这一基本过程的基本知识，并提供用于卫生和生物技术行业的生物传感器和筛查方法。