Defining the cellular impacts of protein aggregation in neurodegenerative disease with an aggreomics platform

使用聚集组学平台定义神经退行性疾病中蛋白质聚集的细胞影响

• 批准号: FT120100039
• 负责人: Prof Daniel Hatters
• 金额: $ 52.11万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT120100039
• 关键词: Defining; cellular; impacts; protein; aggregation

The brain disease Huntington’s is caused by abnormally shaped proteins that assemble into toxic clusters. This project will design new bioprobes to track how these clusters form and cause damage to cells. This strategy will also provide new opportunities for discovering novel therapeutic targets.

脑部疾病亨廷顿氏病是由异常形状的蛋白质组装成有毒簇引起的。该项目将设计新的生物探针来跟踪这些簇如何形成并对细胞造成损害。这一策略也将为发现新的治疗靶点提供新的机会。