课题基金 / 基金详情

BACTERIAL MINICELL MUTANTS

BACTERIAL MINICELL MUTANTS
细菌小细胞突变体
批准号:
3300500
负责人:
LAWRENCE I ROTHFIELD
金额:
$18.49万
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-04-01 至 1992-03-31

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中文摘要
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英文摘要
The long-range objective of this project is to understand the mechanism used by bacterial cells to place the division site at its proper location within the cell. To approach this goal, the bacterial minicell locus (minB) will be studied since mutation of this locus results in aberrant placement of the division septum. The studies are based on recent work showing that the miniB locus codes for several genes that affect the division process. The studies will use a combination of genetics, biochemistry and immunoelectronmicroscopy to localize the minB gene products within the cell, to identify their interactions with each other and with other protein components of the cell division machinery, to probe for possible enzymatic functions of one of the proteins, and to examine the interaction of the minB system with another gene product (dicB) whose effect on the cell division process is likely to be mediated by the minB system.
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Studies of E. coli Min proteins
Studies of E. coli Min proteins
Studies of E. coli Min proteins
Studies of E. coli Min proteins
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