FREE-RADICAL MEDIATED ANNULATIONS AND ADDITIONS

基于自由基介导的[3+2]亚甲基环戊烷的发现 未活化的和富含电子的烯烃的环化 2-苯磺酰亚甲基-环丙烷，本建议旨在开发新的 自由基介导的环化和加成反应。为了实现这一目标， 最初的目标将是开发一系列[3+2]环扎术 允许亚甲基环戊烷环化未活化和 富电子烯烃和一类新的亚甲基环戊烷环 少电子的烯烃。另一个目标是开发新的附加物 未活化的烯烃与α-磺酰基的反应。决赛 我们的目标是，首次开发用于催化的方法 某些自由基的绝对和相对立体化学的控制 骑自行车运动。该项目与健康的相关性源于其影响 关于多种具有重要医学价值的化合物的合成方法 天然和人造物质。

Based on the discovery of the radical mediated [3+2] methylenecyclopentane annulation of unactivated and electron-rich olefins with 2-phenylsulfonylmethylene-cyclopropanes, this proposal aims to develop new free-radical mediated annulation and addition reactions. Toward that end, the initial objective will be to develop a series of [3+2] annulation reagents allowing the methylenecyclopentane annulation of unactivated and electron-rich olefins, and a new class of methylenecyclopentane annulations of electron-poor olefins. Another objective is to develop new addition reactions of unactivated olefins using alpha-sulfonyl radicals. A final objective is to develop, for the first time, methods for the catalytic control of the absolute and relative stereochemistry of some radical cyclizations. The health relatedness of the project derives from its impact on methods for the synthesis of a wide variety of medicinally important natural and artificial substances.