Mechanistic Studies of Nucleophilic Organocatalysis by N-Heterocyclic Carbenes
N-杂环卡宾亲核有机催化机理研究
基本信息
- 批准号:EP/G013268/1
- 负责人:
- 金额:$ 35.33万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2009
- 资助国家:英国
- 起止时间:2009 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Nature uses complex molecules known as enzymes as highly specific catalysts for a multitude of chemical transformations that are essential for biological processes. Although efficient, enzyme reactions often need another molecule, known as a co-factor, to promote specific transformations. In order to further our understanding of these processes, synthetic chemists are constantly trying to engineer artificial molecules that have the ability to mimic enzymatic transformations. There is much current interest in one specific branch of this area of research, which is commonly known as organocatalysis . This technique uses small organic molecules instead of enzymes in order to carry out selective chemical reactions. This proposal aims to develop a fundamental understanding of how one particular class of a simple organic molecule, known as an N-heterocyclic carbene, is able to catalyse a wide range of selective chemical transformations. Nature uses a carbene equivalent as a co-factor in a range of chemical transformations and this proposal seeks to understand why they can be used in the laboratory. By understanding how each step in a particular process works, and by comprehending how the rate of each step changes with a change in catalyst structure, we hope to be able to prepare highly selective and efficient catalysts for the future.
自然界使用被称为酶的复杂分子作为高度特定的催化剂,进行对生物过程至关重要的大量化学转化。尽管效率很高,但酶反应通常需要另一种称为辅助因子的分子来促进特定的转化。为了加深我们对这些过程的理解,合成化学家们不断地试图设计出具有模拟酶转化能力的人造分子。目前人们对这一研究领域的一个具体分支很感兴趣,这就是通常所说的有机催化。这项技术使用有机小分子而不是酶来进行选择性化学反应。这一提议旨在加深对一种特定类型的简单有机分子--N-杂环卡宾--如何能够催化广泛的选择性化学转化的基本理解。自然界在一系列化学转化中使用卡宾当量作为辅助因子,这一提议试图理解为什么它们可以在实验室中使用。通过了解特定过程中每一步的工作原理,以及了解每一步的速度如何随着催化剂结构的变化而变化,我们希望能够为未来制备高选择性和高效的催化剂。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mechanistic studies of azolium ions and their role in organocatalysis
唑离子的机理研究及其在有机催化中的作用
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:Massey Richard Stephen
- 通讯作者:Massey Richard Stephen
Proton transfer reactions of a bridged bis -propyl bis -imidazolium salt
桥联双丙基双咪唑鎓盐的质子转移反应
- DOI:10.1002/poc.3567
- 发表时间:2016
- 期刊:
- 影响因子:1.8
- 作者:Massey R
- 通讯作者:Massey R
Rate and equilibrium constants for the addition of N-heterocyclic carbenes into benzaldehydes: a remarkable 2-substituent effect.
- DOI:10.1002/anie.201501840
- 发表时间:2015-06-01
- 期刊:
- 影响因子:0
- 作者:Collett CJ;Massey RS;Taylor JE;Maguire OR;O'Donoghue AC;Smith AD
- 通讯作者:Smith AD
SYNFORM ISSUE 2013/07
SYNFORM 问题 2013/07
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:AnnMarie O'Donoghue (Interviewee)
- 通讯作者:AnnMarie O'Donoghue (Interviewee)
Proton transfer reactions of N -aryl triazolium salts: unusual ortho -substituent effects
N-芳基三唑盐的质子转移反应:不寻常的邻位取代基效应
- DOI:10.1002/poc.3399
- 发表时间:2014
- 期刊:
- 影响因子:1.8
- 作者:Tucker D
- 通讯作者:Tucker D
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AnnMarie O'Donoghue其他文献
AnnMarie O'Donoghue的其他文献
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{{ truncateString('AnnMarie O'Donoghue', 18)}}的其他基金
Underpinning Mechanistic Studies of NHC-Organocatalysis: A Breslow Intermediate Reactivity Scale
NHC 有机催化的基础机制研究:Breslow 中级反应量表
- 批准号:
EP/S020713/1 - 财政年份:2019
- 资助金额:
$ 35.33万 - 项目类别:
Research Grant
Mechanism of Asymmetric Organocatalysis by Planar Chiral Pyridines of the Addition of Nucleophiles to Ketenes
平面手性吡啶不对称有机催化亲核试剂与乙烯酮加成的机理
- 批准号:
EP/E041531/1 - 财政年份:2007
- 资助金额:
$ 35.33万 - 项目类别:
Research Grant
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