ETIOLOGY OF TRACHEOSOPHAGEAL FISTULA/ESOPHAGEAL ATRESIA

本研究的目的是研究食管癌的流行病学， 闭锁和气管食管瘘（EA/TEF）单独发生或 结合，并确定相关的致病因素， 这些病症的发病机制。 希望这项研究能够发展 一个原型研究设计，用于其他疾病的流行病学调查， 先天性畸形，尤其是消化道畸形， 特别是，畸形事件似乎发生的畸形 在怀孕的最初几周内。 因此，重点将放在 在怀孕前和怀孕前后，而不是怀孕后， 怀孕 对EA/TEF流行病学的深入调查将 通过病例对照研究进行。 数据将从 医院和医生记录以及个人访谈。 的 EA/TEF患者及其家属的特征，特别是 使用各种药物的频率，特别是口服避孕药， 将与对照患者的那些进行比较， 他们的家人调查环境因素 可能在这些疾病的发生中起了作用。 EA/TEF 患者及其家属将与两个对照组进行比较： 病例的兄弟姐妹和无关的临床正常儿童。 第三 由唐氏综合症儿童组成的对照组也将 纳入比较，以评估召回的可能影响 bias. 此外，还将审查与这些因素有关的风险 分别用于EA/TEF以及分离的EA和各种 在人群中观察到的TEF的解剖形式。 的 这项研究的病因学发现可能为预防提供基础 通过改变或消除暴露于特定的致畸因素， 环境

The objective of this research is to study the epidemiology of esophageal atresia and tracheo-esophageal fistula (EA/TEF) occurring separately or in combination and to identify the etiologic factors related to the pathogenesis of these conditions. It is hoped that this study will develop a prototype research design for the epidemiologic investigation of other congenital malformations, especially those of the digestive tract and, in particular, malformations in which the teratologic event appears to occur within the first few weeks of gestation. Thus, the focus will be on exposures prior to and around the time of conception rather than later in pregnancy. An in-depth investigation into the epidemiology of EA/TEF will be carried out through a case-control study. Data will be obtained from hospital and physician records and from personal interviews. The characteristics of EA/TEF patients and their families and in particular the frequency of use of a variety of drugs, especially oral contraceptives and other hormonal agents, will be compared with those of control patients and their families to investigate the possibility that environmental factors may be playing a role in the genesis of these conditions. The EA/TEF patients and their families will be compared with two control groups: siblings of the cases and unrelated clinically normal children. A third control group consisting of children with Down's Syndrome will also be included for comparison in order to assess the possible effects of recall bias. In addition, the risks associated with such factors will be examined separately for EA/TEF as well as for isolated EA and for the various anatomic forms of TEF which are observed in human populations. The etiologic findings of this study may provide the foundation for prevention by modifying or eliminating exposure to specific teratogenic factors in the environment.