ETIOLOGY OF TRACHEOSOPHAGEAL FISTULA/ESOPHAGEAL ATRESIS

本研究的目的是研究食管炎的流行病学。 闭锁和气管食管瘘(EA/TEF)单独发生或 并找出与本病相关的病因。 这些疾病的发病机制。希望这项研究能够得到发展。 非霍乱流行病学调查的原型研究设计 先天性畸形，尤指消化道畸形和先天性畸形 特别的畸形，其中似乎发生了畸胎事件 在怀孕的头几周内。因此，重点将放在 在怀孕前和怀孕前后暴露，而不是在怀孕后 怀孕了。深入调查EA/TEF Will的流行病学 通过病例对照研究进行。数据将从以下地点获得 医院和医生的记录以及个人面谈。这个 EA/TEF患者及其家属的特征，特别是 各种药物的使用频率，特别是口服避孕药和 其他激素剂，将与对照组患者和 他们的家人调查环境因素是否可能 可能在这些疾病的发生中发挥了作用。EA/TEF 患者及其家属将与两个对照组进行比较： 病例的兄弟姐妹和临床上无血缘关系的正常儿童。三分之一 由唐氏综合症儿童组成的对照组也将 列入进行比较，以评估召回可能产生的影响 偏见。此外，还将审查与这些因素相关的风险。 分别用于EA/TEF以及独立的EA和各种 在人类群体中观察到的TEF的解剖形式。这个 本研究的病因学发现可能为预防提供依据。 通过修改或消除对特定致畸因素的暴露 环境。

The objective of this research is to study the epidemiology of esophageal atresia and tracheo-esophageal fistula (EA/TEF) occurring separately or in combination and to identify the etiologic factors related to the pathogenesis of these conditions. It is hoped that this study will develop a prototype research design for the epidemiologic investigation of other congenital malformations, especially those of the digestive tract and, in particular, malformations in which the teratologic event appears to occur within the first few weeks of gestation. Thus, the focus will be on exposures prior to and around the time of conception rather than later in pregnancy. An in-depth investigation into the epidemiology of EA/TEF will be carried out through a case-control study. Data will be obtained from hospital and physician records and from personal interviews. The characteristics of EA/TEF patients and their families and in particular the frequency of use of a variety of drugs, especially oral contraceptives and other hormonal agents, will be compared with those of control patients and their families to investigate the possibility that environmental factors may be playing a role in the genesis of these conditions. The EA/TEF patients and their families will be compared with two control groups: siblings of the cases and unrelated clinically normal children. A third control group consisting of children with Down's Syndrome will also be included for comparison in order to assess the possible effects of recall bias. In addition, the risks associated with such factors will be examined separately for EA/TEF as well as for isolated EA and for the various anatomic forms of TEF which are observed in human populations. The etiologic findings of this study may provide the foundation for prevention by modifying or eliminating exposure to specific teratogenic factors in the environment.