Centre for Doctoral Training in Healthcare Innovation

医疗保健创新博士培训中心

• 批准号: EP/G036861/1
• 负责人: Alison Noble
• 金额: $ 914.17万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Training Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG036861%2F1
• 关键词: Centre; Doctoral; Training; Healthcare; Innovation

This Doctoral Training Centre (DTC) bid concerns developing the next generation of biomedical engineering researchers who, to be competitive in this fast-moving global area of engineering, need not only to be well-equipped with knowledge of modern biomedical engineering (BME) principles and techniques, but also well-versed in translational research skills (principles of clinical trials and commercialization of research). Modern BME research spans a range of technical areas, from hardware devices, to software systems, to artificial organs, biomaterials and drug delivery. It requires engineering researchers to understand biology/physiology relevant to their area, and increasingly multiple engineering disciplines that are only touched on in UK undergraduate education (e.g. modelling and imaging, sensor technology and biomaterials). This new DTC will attract and capture more UK engineering talent to this area and specifically to work at the translational interface. The translational interface takes laboratory-tested devices and methodology through the first steps of clinical validation. This does not just mean running a device or algorithm on a few clinical data sets. It requires close collaboration with clinicians, and deals with understanding how to design tests for a device/system in a clinical scenario and subject to constraints imposed by clinical practice; evaluating the technical and clinical strengths/weaknesses of a technology with the most appropriate statistical methodology; and via this, identifying new academic research questions that can be addressed in the development of the next generation of the technology. It also requires researchers to be aware of ethical issues (research involves patients), and commercialization issues (technology may be patentable and/or start the medical devices approval process). Research at the translational interface is thus fundamental to the advancement of the biomedical engineering field. The skills-base required for this would be most effectively obtained through formal training at the postgraduate level to prepare students for careers in industry or academia. At the University of Oxford we have established a critical mass of biomedical engineering research at the translational interface in the new Institute of Biomedical Engineering (IBME) that would make this training most effectively achieved by establishing a DTC Programme.Three research themes have been identified for the DTC which are closely related to new biomedical research initiatives in the University of Oxford: cancer therapeutics (linked to the new Institute of Cancer Medicine and Oxford Cancer Hospital); modelling for personalised healthcare (linked to the Oxford Acute Vascular Imaging Centre), and information-driven healthcare (linked to recent successful bids from the recent EPSRC Digital Economy call).Postgraduate students on the DTC will participate in an intensive training programme in their first year, including a hospitial internship, modules on BME foundations (modelling, signals/systems, experimental methods), each of the 3 research themes, commercialization and entrepreneurship, and statistical methods and clinical trials. Students will also undertake 2 short projects, one of which must take place in industry or a hospital. One of the projects will become their doctoral research project. In yrs 2-4 the main focus is the research project, with an option to spend time visiting an international laboratory. Throughout there will be a programme of research skills training, and opportunities to engage with industry.The proposal has strong support from our clinical collaborators and industry players both large and small.

该博士培训中心（DTC）申办涉及培养下一代生物医学工程研究人员，为了在这个快速发展的全球工程领域具有竞争力，他们不仅需要具备现代生物医学工程（BME）的知识。原则和技术，而且精通转化研究技能（临床试验原则和研究商业化）。现代BME研究跨越了一系列技术领域，从硬件设备到软件系统，再到人工器官，生物材料和药物输送。它要求工程研究人员了解与其领域相关的生物学/生理学，以及越来越多的仅在英国本科教育中涉及的工程学科（例如建模和成像，传感器技术和生物材料）。这个新的DTC将吸引和捕获更多的英国工程人才到这一领域，特别是在翻译接口工作。翻译接口通过临床验证的第一步采用实验室测试的设备和方法。这不仅仅意味着在几个临床数据集上运行设备或算法。它需要与临床医生密切合作，并涉及了解如何在临床场景中设计器械/系统的测试，并受到临床实践的限制;使用最适当的统计方法评估技术的技术和临床优势/弱点;并通过此，确定可以在下一代技术开发中解决的新学术研究问题。它还要求研究人员了解伦理问题（研究涉及患者）和商业化问题（技术可能获得专利和/或启动医疗器械审批程序）。因此，在平移界面的研究是生物医学工程领域的进步的基础。通过研究生一级的正规培训，为学生进入工业界或学术界做好准备，可以最有效地获得这方面所需的技能基础。在牛津大学，我们已经在新的生物医学工程研究所（IBME）的翻译界面上建立了生物医学工程研究的临界质量，这将通过建立DTC计划来最有效地实现这种培训。DTC已经确定了三个研究主题，这些主题与牛津大学新的生物医学研究计划密切相关：癌症治疗剂（与新的癌症医学研究所和牛津癌症医院有联系）;个性化医疗建模（链接到牛津急性血管成像中心），和信息驱动的医疗保健（链接到最近EPSRC数字经济电话会议的最近成功竞标）。DTC的研究生将在第一年参加强化培训计划，包括医院实习，BME基础模块（建模，信号/系统，实验方法），3个研究主题，商业化和创业精神，统计方法和临床试验。学生还将承担2个短期项目，其中一个必须在工业或医院进行。其中一个项目将成为他们的博士研究项目。在第2 - 4年的主要重点是研究项目，并选择花时间参观国际实验室。在整个过程中，将有一个研究技能培训计划，并有机会与行业接触。该提案得到了我们的临床合作者和行业参与者的大力支持。