Quantitative 4D Echocardiography using Fusion Techniques and Spatio-temporal Analysis

使用融合技术和时空分析的定量 4D 超声心动图

• 批准号: EP/G030693/1
• 负责人: Alison Noble
• 金额: $ 74.16万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG030693%2F1
• 关键词: Quantitative; 4D; Echocardiography; using; Fusion

4D echocardiography (or real-time 3D echocardiography) is a recent addition to the volumetric cardiac imaging field which is receiving significant clinical interest as it may replace the need for more expensive techniques (MRI) and also suggest new areas of application for volumetric cardiac imaging e.g. in interventions. This research project, building on the succces of EPSRC GR/S72801, concerns quantitative 4D echocardiography, and in particular developing quantitative methods for estimating global and regional functional measures of the health of the heart from 4D echocardiography The novelty in the project is built on two principal ideas.1. Fused 4D echocardiography: an idea, initially investigated in EPSRC GR/S72801, of fusing information from 2 or more 4D acquisitions to get an anatomically more complete representation of the structure/function of a heart than can be obtained from a single acquisition. In prior work we developed methodology for fusion and showed it led to superior 3D images. In this new project we plan to investigate automated quantitative analysis (segmentation) which we hypothese will be superior on fused 4D echocardiography. We will also investigate techniques for combined alignment (registration) and segmentation which is a natural next step to investigate towards making quantitative fused 4D echocardiography fully automated and hence useful in clinical practice. 2. Analysis of combined rest and stress echocardiographic sequences: Stress echocardiography is a widely used test in clinical practice where imaging is done when the heart is at rest and then after it has been stressed. The limited work on quantitative image analysis of stress echocardiography has treated rest and stress sequences separately even though it is the relative difference between the two that is used in clinical diagnosis. The novel idea in this part of the project is to use both pre and post stress sequences to define a model of healthy/abnormal function (mathematically a Hidden Markov Model) which is learned from training sequences. We do this on volumetric data. In the project we will build such models and apply them to initially classify disease and then as a constraint in segmentation.Both developments will advance clinical 4D echocardiography, and 3D cardiac imaging more generally. The developed tools may also find application in non-cardiac applications, such as in obstetrics and gynaecology (assessing the health of the uterus), or oncology (tumour response to treatment).

4D超声心动图（或实时3D超声心动图）是最近添加到体积心脏成像领域的新技术，其正受到显著的临床关注，因为其可以取代对更昂贵的技术（MRI）的需求，并且还提出了体积心脏成像的新应用领域，例如在介入中。该研究项目建立在EPSRC GR/S72801的成功基础上，涉及定量4D超声心动图，特别是开发用于从4D超声心动图估计心脏健康的整体和区域功能测量的定量方法。融合4D超声心动图：最初在EPSRC GR/S72801中研究的一种想法，即融合来自2个或多个4D采集的信息，以获得比单次采集更完整的心脏结构/功能解剖学表示。在以前的工作中，我们开发了融合的方法，并表明它导致了上级3D图像。在这个新的项目中，我们计划研究自动定量分析（分割），我们假设这将是上级融合四维超声心动图。我们还将研究组合对齐（配准）和分割的技术，这是研究定量融合4D超声心动图完全自动化的自然下一步，因此在临床实践中很有用。2.静息和负荷超声心动图组合序列的分析：负荷超声心动图是临床实践中广泛使用的测试，其中在心脏静息时以及在心脏受压后进行成像。负荷超声心动图定量图像分析的有限工作已经分别处理了静息和负荷序列，即使这是两者之间的相对差异，用于临床诊断。该项目这一部分的新颖想法是使用压力前和压力后序列来定义从训练序列中学习的健康/异常功能模型（数学上为隐马尔可夫模型）。我们在体积数据上这样做。在该项目中，我们将建立这样的模型，并将其应用于疾病的初步分类，然后作为分割的约束条件。这两项发展将推进临床4D超声心动图，以及更普遍的3D心脏成像。所开发的工具也可以应用于非心脏应用，例如妇产科（评估子宫健康）或肿瘤学（肿瘤对治疗的反应）。

项目成果

CMR right ventricular strain assessment using feature tracking cine images: agreement with echocardiography

• DOI: 10.1186/1532-429x-14-s1-p244
• 发表时间: 2012-02-01
• 期刊: Journal of Cardiovascular Magnetic Resonance
• 影响因子: 6.4
• 作者: Augustine D;Suttie JJ;Cox P;Lewandowski AJ;Holloway C;Petersen SE;Myerson S;Neubauer S;Leeson P
• 通讯作者: Leeson P

Global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender.

全球和区域左心室心肌变形测量通过磁共振特征跟踪健康志愿者：与性别的标记和相关性进行比较。

• DOI: 10.1186/1532-429x-15-8
• 发表时间: 2013-01-18
• 期刊: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
• 作者: Augustine D;Lewandowski AJ;Lazdam M;Rai A;Francis J;Myerson S;Noble A;Becher H;Neubauer S;Petersen SE;Leeson P
• 通讯作者: Leeson P

"3D fusion" echocardiography improves 3D left ventricular assessment: comparison with 2D contrast echocardiography.

“3D 融合”超声心动图改善了 3D 左心室评估：与 2D 对比超声心动图的比较。

• DOI: 10.1111/echo.12655
• 发表时间: 2015
• 期刊: Echocardiography (Mount Kisco, N.Y.)
• 作者: Augustine D

3D fusion echocardiography improves 3D left ventricular assessment: comparison with 2D contrast

3D 融合超声心动图改善 3D 左心室评估：与 2D 对比对比

• 作者: Daniel Augustine (Author)

Aortic stiffness and blood pressure variability in young people: a multimodality investigation of central and peripheral vasculature.

年轻人的主动脉僵硬和血压变异性：中央和周围脉管系统的多模式研究。

• DOI: 10.1097/hjh.0000000000001192
• 发表时间: 2017-03
• 期刊: Journal of hypertension
• 影响因子: 4.9
• 作者: Boardman H;Lewandowski AJ;Lazdam M;Kenworthy Y;Whitworth P;Zwager CL;Francis JM;Aye CY;Williamson W;Neubauer S;Leeson P
• 通讯作者: Leeson P