REMOTE STIMULATION BY RADIOFREQUENCY TRANSMISSION

本研究的主要目的是：临床研究。要继续，请继续 条件反射条件下不间断起搏的实验研究 呼吸麻痹患者的疲劳感。开展一项详细的 中央型心绞痛患者的现状及病程回顾 隔膜起搏治疗肺泡低通气性 耶鲁-纽黑文医学中心，努力找出那些 影响这类患者的预后。特别强调的是 关于以下方面的研究：1)神经系统表现；2) 对“正常”低氧、高二氧化碳高氧血症的呼吸机能反应 实施隔膜起搏前的高二氧化碳低氧和 之后；3)起搏开始和起搏时使用的电参数 随后；4)隔膜起搏前后的运动； (5)隔膜起搏前后出现上呼吸道阻塞； 6)肺功能，包括呼吸和灌注肺扫描， 起搏前后；7)起搏和起搏的原因 CAH患者需要双侧横隔肌起搏的频率； 8)似乎与之相关或受其影响的呼吸道并发症 通过起搏技术；9)跨膈压(PDI)；和10) 使用加速度计技术对横隔膜进行调节 快步走。更新关于隔膜的国内(和国际)注册 快步走。实验研究。对完全可植入的膈肌进行评估 神经刺激器和编程器的新设计(脉宽调制)。 探索最佳脉冲频率和脉冲串重复率 隔膜的间歇性起搏，a)用于通风支持，b)用于 控制单支的横隔膜成分。

The major objectives of this research are: Clinical Studies. To continue the study of uninterrupted pacing of the diaphragm conditioned to resist fatigue in patients with respiratory paralysis. To carry out a detailed review of the present status and past course of patients with central alveolar hypoventilation (CAH) treated by diaphragm pacing (DP) at the Yale-New Haven Medical Center in an effort to identify those factors that affect the prognosis of this type of patient. Particular emphasis will be on studies concerning: 1) the neurologic manifestations; 2) the ventilatory response to "normocapnic" hypoxia, hypercapnic hyperoxia and hypercapnic hypoxia prior to the instituting of diaphragm pacing and afterwards; 3) the electrical parameters used at the start of pacing and subsequently; 4) the movement of the diaphragm on and off diaphragm pacing; 5) the occurrence of upper airway obstruction on and off diaphragm pacing; 6) the pulmonary function, including ventilation and perfusion lung scans, prior to the institution of pacing and afterwards; 7) the causes for and the frequency of the need to pace both hemidiaphragms in patients with CAH; 8) the respiratory complications that appear to be related to or influenced by the pacing technique; 9) the transdiaphragmatic pressure (Pdi); and 10) the conditioning of the diaphragm using the accelerometer technique during pacing. To update the national (and international) registry on diaphragm pacing. Experimental Studies. To evaluate to totally implantable phrenic nerve stimulator and programmer of a new design (pulse width modulated). To explore the optimum pulse frequency and pulse train repetition rate for intermittent pacing of the diaphragm, a) for ventilatory support, b) for controlling the diaphragmatic component of singultus.