REMOTE STIMULATION BY RADIOFREQUENCY TRANSMISSION

通过射频传输进行远程刺激

• 批准号: 3334185
• 负责人: WILLIAM W GLENN
• 金额: $ 22.99万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1987-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3334185
• 关键词: action potentials; autogenic training; biomedical registry /referral center; biopsy; blood flow measurement; clinical biomedical equipment; electron microscopy; endoscopy; histochemistry /cytochemistry; human subject; longitudinal human study; muscle contraction; neural transmission; neuromuscular stimulator; paralysis; patient /disease registry; phrenic nerve; radio controlled electronic stimulator; respiratory airflow disorder; respiratory function; respiratory hypoxia; respiratory insufficiency /failure; respiratory muscles; telemedicine

The major objectives of this research are: Clinical Studies. To continue the study of uninterrupted pacing of the diaphragm conditioned to resist fatigue in patients with respiratory paralysis. To carry out a detailed review of the present status and past course of patients with central alveolar hypoventilation (CAH) treated by diaphragm pacing (DP) at the Yale-New Haven Medical Center in an effort to identify those factors that affect the prognosis of this type of patient. Particular emphasis will be on studies concerning: 1) the neurologic manifestations; 2) the ventilatory response to "normocapnic" hypoxia, hypercapnic hyperoxia and hypercapnic hypoxia prior to the instituting of diaphragm pacing and afterwards; 3) the electrical parameters used at the start of pacing and subsequently; 4) the movement of the diaphragm on and off diaphragm pacing; 5) the occurrence of upper airway obstruction on and off diaphragm pacing; 6) the pulmonary function, including ventilation and perfusion lung scans, prior to the institution of pacing and afterwards; 7) the causes for and the frequency of the need to pace both hemidiaphragms in patients with CAH; 8) the respiratory complications that appear to be related to or influenced by the pacing technique; 9) the transdiaphragmatic pressure (Pdi); and 10) the conditioning of the diaphragm using the accelerometer technique during pacing. To update the national (and international) registry on diaphragm pacing. Experimental Studies. To evaluate to totally implantable phrenic nerve stimulator and programmer of a new design (pulse width modulated). To explore the optimum pulse frequency and pulse train repetition rate for intermittent pacing of the diaphragm, a) for ventilatory support, b) for controlling the diaphragmatic component of singultus.

这项研究的主要目标是： 临床研究。 继续 膈肌不间断起搏的研究 呼吸麻痹患者的疲劳。 为进行详细 回顾中枢神经系统疾病患者的现状和既往病程 膈肌起搏（DP）治疗肺泡通气不足（CAH） 耶鲁-纽黑文医学中心努力确定那些因素 影响该类患者的预后。 将特别强调的是 研究涉及：1）神经系统表现； 2） 对“正常碳酸血症”缺氧、高碳酸血症高氧和的通气反应 在进行膈肌起搏之前出现高碳酸血症性缺氧 然后; 3) 起搏开始时使用的电参数和 随后; 4）膈肌开启和关闭膈肌起搏的运动； 5) 膈肌起搏时发生上气道阻塞； 6) 肺功能，包括通气和灌注肺扫描， 在开始起搏之前和之后； 7) 原因和 CAH 患者需要起搏两侧膈肌的频率； 8) 似乎与此相关或受影响的呼吸系统并发症 通过起搏技术； 9) 跨膈压力（Pdi）；和 10) 在过程中使用加速度计技术调节隔膜 踱步。 更新隔膜的国家（和国际）注册 踱步。 实验研究。 评估完全植入式膈 新设计的神经刺激器和编程器（脉冲宽度调制）。 探索最佳脉冲频率和脉冲串重复率 膈肌间歇起搏，a) 用于通气支持，b) 用于 控制singultus的膈肌成分。