REMOTE STIMULATION BY RADIOFREQUENCY TRANSMISSION

本研究的主要目的是：临床研究。 继续 对隔膜不间断起搏的研究， 疲劳呼吸麻痹患者。 进行详细 回顾中枢神经系统疾病患者的现状和既往病程 肺泡通气不足（CAH），通过膈肌起搏（DP）治疗， 耶鲁-纽黑文医学中心在努力确定这些因素， 影响这类患者的预后。 将特别强调 关于以下方面的研究：1）神经学表现; 2） 对“正常碳酸血症”缺氧、高碳酸血症高氧和 隔膜起搏前的高碳酸血症性缺氧， 3）起搏开始时使用的电参数， 随后; 4）隔膜的运动，隔膜起搏和隔膜起搏; 5)上呼吸道阻塞的发生率; 6)肺功能，包括通气和灌注肺扫描， 起搏前和起搏后; 7）起搏的原因和 CAH患者双侧膈肌起搏的频率; 8)似乎与呼吸系统并发症有关或受其影响 通过起搏技术; 9）经颅压（Pdi）;和10） 使用加速度计技术调节隔膜， 起搏 更新关于隔膜的国家（和国际）注册表 起搏 实验研究。 评价完全植入式膈神经 新设计的神经刺激器和程控仪（脉宽调制）。 探索最佳脉冲频率和脉冲序列重复率， 间歇性膈肌起搏，a）用于辅助支持，B）用于 控制着奇点的运动成分。

The major objectives of this research are: Clinical Studies. To continue the study of uninterrupted pacing of the diaphragm conditioned to resist fatigue in patients with respiratory paralysis. To carry out a detailed review of the present status and past course of patients with central alveolar hypoventilation (CAH) treated by diaphragm pacing (DP) at the Yale-New Haven Medical Center in an effort to identify those factors that affect the prognosis of this type of patient. Particular emphasis will be on studies concerning: 1) the neurologic manifestations; 2) the ventilatory response to "normocapnic" hypoxia, hypercapnic hyperoxia and hypercapnic hypoxia prior to the instituting of diaphragm pacing and afterwards; 3) the electrical parameters used at the start of pacing and subsequently; 4) the movement of the diaphragm on and off diaphragm pacing; 5) the occurrence of upper airway obstruction on and off diaphragm pacing; 6) the pulmonary function, including ventilation and perfusion lung scans, prior to the institution of pacing and afterwards; 7) the causes for and the frequency of the need to pace both hemidiaphragms in patients with CAH; 8) the respiratory complications that appear to be related to or influenced by the pacing technique; 9) the transdiaphragmatic pressure (Pdi); and 10) the conditioning of the diaphragm using the accelerometer technique during pacing. To update the national (and international) registry on diaphragm pacing. Experimental Studies. To evaluate to totally implantable phrenic nerve stimulator and programmer of a new design (pulse width modulated). To explore the optimum pulse frequency and pulse train repetition rate for intermittent pacing of the diaphragm, a) for ventilatory support, b) for controlling the diaphragmatic component of singultus.