ENDOCRINE FUNCTIONS OF THE PLACENTA

我计划研究胎盘的产生和调节 产生类花生酸（前列环素，血栓素， 羟基二十碳四烯酸（HETE）和白三烯）， 正常妊娠和妊娠合并高血压 （先兆子痫）。 先兆子痫是导致胎儿死亡的主要原因之一， 生长迟缓、早产和产妇死亡。 将在体外培养人胎盘组织， 生产率和监管因素。 类花生酸将是 通过放射免疫测定法测量。 具体来说，我将研究：1） 调节胎盘前列环素和血栓素的产生， 以及它们的不平衡增加的病因 血栓素/降低的前列环素在先兆子痫; 2） 胎盘HETE和白三烯的调节及其病因 5-和12-脂氧合酶缺乏的先兆子痫; 3） 环加氧酶之间存在的调节相互作用 （胰高血糖素和血栓素）和脂氧合酶（HETE和 花生四烯酸代谢的白三烯产物; 4） 正常和先兆子痫患者的白三烯生成率 胎盘

I plan to study the production and regulation of placentally produced eicosanoids (prostacyclin, thromboxane, hydroxyeicosatetraenoic acids (HETEs) and leukotrienes) in both normal pregnancies and pregnancies complicated by hypertension (preecalmpsia). Preeclampsia is one of the leading causes of fetal growth retardation, premature delivery and maternal death. Human placental tissues will be incubated in vitro to study production rates and regulatory factors. Eicosanoids will be measured by radioimmunoassay. Specifically, I will study: 1) the regulation of placental prostacyclin and thromboxane production, and the etiology of their imbalance of increased thromboxane/decreased prostacyclin in preeclampsia; 2) the regulation of placental HETEs and leukotrienes and the etiology of the 5- and 12-lipoxygenase deficiencies in preeclampsia; 3) the regulatory interactions that exist between the cyclooxygenase (prostaglandins and thromboxane) and lipoxygenase (HETEs and leukotrienes products of arachidonic acid metabolism; 4) the production rates of leukotrienes in normal and preeclamptic placentas.