MASS TRANSFER IN THE MICROCIRCULATION

微循环中的传质

• 批准号: 3335966
• 负责人: J. DAVID HELLUMS
• 金额: $ 11.54万
• 依托单位: RICE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1992-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3335966
• 关键词: capillary; computer simulation; erythrocytes; heme; hemoglobin As; mathematical model; microcirculation; microelectrodes; micromanipulator; microspectrophotometry; oxygen consumption; oxygen transport; respiratory gas transport; respiratory oxygenation; vascular resistance

The objectives of the current work are to place the important field of research on mathematical simulation of the microcirculation on the stronger base and to obtain direct experimental confirmation of the validity of the results. A simplified analysis has been completed which indicates that the resistance to oxygen transfer in the capillaries is much higher than previously reported. Numerical solutions of the partial differential equations of oxygen transport indicate the relative importance of the various parameters and show the need for careful treatment of the oxyhemoglobin diffusion and reaction kinetics expressions. It is proposed to carry out numerical solutions of the equations of oxygen transport in the cylindrical geometry for the ranges of the parameters of primary interest in the microcirculation. Additional approximate analyses will be carried out to estimate oxygen fluxes in the plasma, and to reduce the results of the numerical solutions to forms of practical utility. The experimental work will involve fabrication of 5 to 10 micron diameter capillaries of silicone rubber. Direct determination of hemoglobin saturation changes will be made in red cell suspensions flowing in the capillaries. Measurements of heme absorbance will be used to monitor oxygen transport over a wide range of conditions.

当前工作的目标是对重要的研究领域进行定位