MASS TRANSFER IN THE MICROCIRCULATION

当前工作的目标是把重要的研究领域 关于强基上微循环的数学模拟 获得对结果有效性的直接实验确认。 一个简化的分析已经完成，它表明对 毛细血管中的氧气转移比以前报道的要高得多。 氧气输运偏微分方程组的数值解 指出各种参数的相对重要性，并说明 氧合血红蛋白扩散和反应动力学的谨慎处理 表情。 建议对氧气方程进行数值求解。 参数范围在柱面几何中的输运 对微循环的主要兴趣。其他近似分析将 以估计等离子体中的氧通量，并减少 实用形式的数值解的结果。这个 实验工作将包括制造5到10微米直径 硅橡胶的毛细血管。直接测定血红蛋白饱和度 将对流动在毛细血管中的红细胞悬浮液进行改变。 血红素吸光度的测量将用于监测氧气在 条件很广。

The objectives of the current work are to place the important field of research on mathematical simulation of the microcirculation on the stronger base and to obtain direct experimental confirmation of the validity of the results. A simplified analysis has been completed which indicates that the resistance to oxygen transfer in the capillaries is much higher than previously reported. Numerical solutions of the partial differential equations of oxygen transport indicate the relative importance of the various parameters and show the need for careful treatment of the oxyhemoglobin diffusion and reaction kinetics expressions. It is proposed to carry out numerical solutions of the equations of oxygen transport in the cylindrical geometry for the ranges of the parameters of primary interest in the microcirculation. Additional approximate analyses will be carried out to estimate oxygen fluxes in the plasma, and to reduce the results of the numerical solutions to forms of practical utility. The experimental work will involve fabrication of 5 to 10 micron diameter capillaries of silicone rubber. Direct determination of hemoglobin saturation changes will be made in red cell suspensions flowing in the capillaries. Measurements of heme absorbance will be used to monitor oxygen transport over a wide range of conditions.