EPIDEMIOLOGY OF PLACENTA PREVIA AND ABRUPTIO PLACENTA

前置胎盘和胎盘早剥的流行病学

• 批准号: 3326260
• 负责人: BETH A MUELLER
• 金额: $ 14.45万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3326260
• 关键词: age at pregnancy; alcoholic beverage consumption; case history; cesarean section; disease /disorder proneness /risk; drug abuse; epidemiology; induced abortion; interview; lifestyle; placenta disorders; pregnancy loss; socioeconomics; statistics /biometry; tobacco abuse

Placenta previa (implantation of the placenta over the cervical os) and abruptio placenta (premature separation of a normally implanted placenta from the uterine wall) are serious problems of pregnancy. Abruption is responsible for over 20% of perinatal mortality, and the occurrence of placenta previa may comprise both the health of the mother and child; both generally require a C-section delivery. Very few studies of these conditions have been done; however, there is some evidence from case series that exposures such as prior C-section, induced abortion, smoking, and alcohol use may increase a woman's risk. Illicit drug use, specifically cocaine use, may also increase the risk for abruption. Until now, these exposures were not common enough to be evaluated as risk factors using case-control methods. The proposed is a multi-center, case- control study of placenta previa and abruptio placenta which will identify cases and controls from five hospitals for a three-year period. Subjects will be interviewed concerning their lifestyle (smoking and drug and alcohol use prior to conception and prenatally); reproductive histories (prior outcomes such as induced abortion and C-section); and other factors. Multivariate logistic regression will be used to analyze the effect these factors have on the occurrence and severity of placenta previa and abruptio placenta. Factors such as age, parity, and socioeconomic status will also be evaluated as potential risks and to determine their possible modifying effects for the reproductive and lifestyle exposures. The results of this study will demonstrate how exposures prior to conception may increase a woman's risk for placenta previa and how preconception and prenatal exposures may affect her risk for abruptio placenta.

前置胎盘（胎盘植入宫颈口）和 胎盘早剥（正常植入的胎盘过早分离） 从子宫壁）是严重的怀孕问题。早剥 造成20%以上的围产期死亡， 前置胎盘可能同时影响母亲和婴儿的健康; 一般都需要剖腹产很少有研究表明， 条件已经做了;然而，有一些证据，从案件 一系列的暴露，如先前的剖腹产，人工流产，吸烟， 饮酒可能会增加女性患病的风险。非法药物使用， 特别是可卡因的使用，也可能增加吸毒的风险。直到 现在，这些暴露还没有普遍到足以被评估为风险 使用病例对照方法。这是一个多中心的案例- 前置胎盘与胎盘脱垂的对照研究 在三年的时间里，从五家医院确定病例和对照。 将对受试者进行有关其生活方式（吸烟和吸毒）的访谈 怀孕前和产前饮酒）;生殖 病史（既往结果，如人工流产和剖腹产）;以及 其他因素将使用多变量logistic回归分析 这些因素对胎盘发生和严重程度的影响 前置和胎盘前置。年龄、产次等因素 社会经济状况也将被评估为潜在风险， 确定其可能的修改影响的生殖和 生活方式暴露。这项研究的结果将证明如何 怀孕前的暴露可能会增加女性胎盘的风险 以及孕前和产前暴露如何影响她的风险 治疗胎盘炎